Consolidated Statements of Changes in Stockholders’ Equity (Parentheticals) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Statement of Stockholders' Equity [Abstract]
Issuance of common stock and warrants	$ 572,500	$ 806,243
Issuance of common stock		$ 525,000
Issuance of common stock, common stock warrants and prefunded warrants	$ 1,591,600