<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Hewlett Fund LP -->
          <cik>0001711607</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>COMMON STOCK, $0.001 PAR VALUE PER SHARE</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>05/19/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001095981</issuerCik>
        <issuerName>Plus Therapeutics, Inc.</issuerName>
        <issuerCusip>72941H509</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>2710 Reed Rd.</com:street1>
          <com:street2>Suite 160</com:street2>
          <com:city>Houston</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>77051</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>The Hewlett Fund LP</reportingPersonName>
      <citizenshipOrOrganization>NY</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2006552.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>2006552.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2006552.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>8.255</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>Note to 5, 7, 9 and 11: Based on 24,307,166 shares outstanding as of May 19, 2025 as reported by the Issuer's transfer agent.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Plus Therapeutics, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>2710 Reed Rd., Suite 160, Houston, TX 77051</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>The Hewlett Fund LP</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>100 Merrick Road, Suite 400W, Rockville Centre, NY 11570</principalBusinessOfficeOrResidenceAddress>
        <citizenship>New York</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>2,006,552.00</amountBeneficiallyOwned>
        <classPercent>8.255%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>2,006,552.00</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0 Shares</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>2,006,552.00</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0 Shares</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>The Hewlett Fund LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Martin Chopp</signature>
        <title>Martin Chopp, General Partner</title>
        <date>05/22/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
