X0306 4 2020-12-11 0 0001537917 TYME TECHNOLOGIES, INC. TYME 0001711342 Hoffman Steve C/O TYME TECHNOLOGIES, INC. 1 PLUCKEMIN WAY, SUITE 103 BEDMINSTER NJ 07921 1 1 1 0 Chief Science Officer Common Stock 2020-12-11 4 S 0 184633 1.27 D 25465615 D Common Stock 2020-12-14 4 S 0 315367 1.20 D 25150248 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.25 to $1.33, inclusive, on December 11, 2020. The reporting person undertakes to provide to Tyme Technologies, Inc., any security holder of Tyme Technologies, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1) and (2) of this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.13 to $1.30, inclusive, on December 14, 2020. By: /s/ Steve Hoffman 2020-12-15