144 0001198325 XXXXXXXX LIVE 0001711279 Krystal Biotech, Inc. 001-38210 2100 WHARTON STREET SUITE 701 PITTSBURGH PA 15203 (412) 586-5830 JANNEY DANIEL Director COMMON MERRILL LYNCH

555 CALIFORNIA ST SAN FRANCICSCO CA 94104

50000 6400000.00 25799738 06/08/2023 NASDAQ COMMON 08/25/2017 PRIVATE PURCHASE ISSUER - KRYSTAL BIOTECH N 50000 08/25/2017 CASH N DANIEL JANNEY - ALTA BIOEQUITIES, LP

C/O KRYSTAL BIOTECH 2100 WHARTON ST, STE 701 PITTSBURGH PA 15203

COMMON 04/19/2023 7900 713166.00 DANIEL JANNEY - ALTA BIOEQUITIES, LP

C/O KRYSTAL BIOTECH 2100 WHARTON ST, STE 701 PITTSBURGH PA 15203

COMMON 05/09/2023 17100 1550877.00 DANIEL JANNEY - ALTA BIOEQUITIES, LP

C/O KRYSTAL BIOTECH 2100 WHARTON ST, STE 701 PITTSBURGH PA 15203

COMMON 05/19/2023 50000 4749141.00 06/08/2023 DANIEL JANNEY - ALTA BIOEQUITIES, LP