<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001198325</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001711279</issuerCik>
      <issuerName>Krystal Biotech, Inc</issuerName>
      <secFileNumber>001-38210</secFileNumber>
      <issuerAddress>
        <com:street1>2100 Wharton Street</com:street1>
        <com:street2>Suite 701</com:street2>
        <com:city>Pittsburgh</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>15203</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>4125865830</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Daniel S Janney</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>555 California Street</com:street1>
          <com:street2>STE 1800</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>11803</noOfUnitsSold>
      <aggregateMarketValue>3252823.82</aggregateMarketValue>
      <noOfUnitsOutstanding>29232189</noOfUnitsOutstanding>
      <approxSaleDate>02/27/2026</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>08/25/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11803</amountOfSecuritiesAcquired>
      <paymentDate>08/25/2017</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Daniel S Janney</name>
        <address>
          <com:street1>2100 Wharton Street</com:street1>
          <com:street2>Suite 701</com:street2>
          <com:city>Pittsburgh</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>15203</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/24/2026</saleDate>
      <amountOfSecuritiesSold>37895</amountOfSecuritiesSold>
      <grossProceeds>10113354.42</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Daniel S Janney</name>
        <address>
          <com:street1>2100 Wharton Street</com:street1>
          <com:street2>Suite 701</com:street2>
          <com:city>Pittsburgh</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>15203</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/24/2026</saleDate>
      <amountOfSecuritiesSold>13825</amountOfSecuritiesSold>
      <grossProceeds>3709850.15</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Daniel S Janney</name>
        <address>
          <com:street1>2100 Wharton Street</com:street1>
          <com:street2>Suite 701</com:street2>
          <com:city>Pittsburgh</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>15203</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/25/2026</saleDate>
      <amountOfSecuritiesSold>700</amountOfSecuritiesSold>
      <grossProceeds>192500</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Daniel S Janney</name>
        <address>
          <com:street1>2100 Wharton Street</com:street1>
          <com:street2>Suite 701</com:street2>
          <com:city>Pittsburgh</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>15203</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/26/2026</saleDate>
      <amountOfSecuritiesSold>7741</amountOfSecuritiesSold>
      <grossProceeds>2133679.5</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Shares sold via Alta Bioequities LP</remarks>
    <noticeSignature>
      <noticeDate>02/27/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>11/25/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Daniel S Janney</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
