X0306 4 2018-06-01 0 0001711279 Krystal Biotech, Inc. KRYS 0001298711 Krishnan Suma C/O KRYSTAL BIOTECH, INC. 2100 WHARTON STREET, SUITE 701 PITTSBURGH PA 15203 1 1 1 0 Chief Operating Officer Common Stock 2018-06-01 4 J 0 16213 A 1951462 D Common Stock 112162 I By trust Common Stock 2011462 I By spouse Award of restricted stock. Directly beneficially owned by the Krishnan Family Trust. The reporting person and her spouse are each joint beneficial owners of the trust with joint voting and investment control. Directly beneficially owned by Krish S. Krishnan, the spouse of the reporting person. /s/ Emiko Kurotsu, as attorney-in-fact for Suma Krishnan 2018-06-05