X0306 4 2021-02-26 0 0001711279 Krystal Biotech, Inc. KRYS 0001298709 Krishnan Krish S C/O KRYSTAL BIOTECH, INC. 2100 WHARTON STREET, SUITE 701 PITTSBURGH PA 15203 1 1 1 0 President and CEO Common Stock 2021-02-26 4 A 0 40800 A 1927262 D Common Stock 112162 I By trust Common Stock 1864464 I By spouse Stock Option (Right to Buy) 78.89 2021-02-26 4 A 0 61200 0.00 A 2025-02-26 Common Stock 61200 61200 D Award of restricted stock which vests in four equal annual installments beginning on February 26, 2022. Directly beneficially owned by the Krishnan Family Trust. The reporting person and his spouse are each joint beneficial owners of the trust with joint voting and investment control. Directly beneficially owned by Suma S. Krishnan, the spouse of the reporting person. The option vests in four equal annual installments beginning on February 26, 2022. /s/ Krish Krishnan 2021-03-02