X0306 4 2018-11-07 0 0001098972 AGENUS INC AGEN 0001711184 Buell Jennifer C/O AGENUS INC. 3 FORBES ROAD LEXINGTON MA 02421 0 1 0 0 Chief Operating Officer Stock Option (right to buy) 2.07 2018-11-07 4 A 0 130000 0.00 A 2027-11-07 Common Stock 130000 130000 D Represents the grant of an option to purchase shares of common stock. The stock option was awarded in accordance with the Agenus Inc. Amended and Restated 2009 Equity Investment Plan, and vests over three years with one-third of the award vesting on November 7, 2019 and the balance vesting in equal quarterly installments thereafter. /s/ Evan D. Kearns, by Power of Attorney 2018-11-14