X0306 4 2019-11-11 0 0001785173 89bio, Inc. ETNB 0001711080 Grunberg Gregory C/O 89BIO, INC. 535 MISSION STREET, 14TH FLOOR SAN FRANCISCO CA 94105 1 0 1 0 Common Stock 2019-11-11 4 P 0 575000 16.00 A 575000 I See footnote Common Stock 2019-11-13 4 C 0 1916787 A 2491787 I See footnote Series A Preferred Stock 2019-11-13 4 C 0 11916667 0.00 D Common Stock 1916787 0 I See footnote On November 11, 2019, Longitude Venture Partners III, L.P. ("Longitude Venture III") purchased 575,000 shares of the Issuer's common stock at a price of $16.00 per share in the Issuer's initial public offering. The Series A Preferred Stock automatically converted into shares of the Issuer's common stock on a one-for-6.217 basis immediately prior the closing of the Issuer's initial public offering on November 13, 2019 and had no expiration date. These shares are held directly by Longitude Venture III. Longitude Capital Partners III, LLC ("Longitude Capital III") is the general partner of Longitude Venture III. The Reporting Person is a member of Longitude Capital III and may be deemed to share voting, investment and dispositive power with respect to these securities. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interests therein. /s/ Ryan A. Murr, Attorney-in-Fact for Gregory Grunberg 2019-11-13