October 13, 2021

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549-4720

Re:	American Century ETF Trust (the “Registrant”)
	1933 Act File No. 333-221045, Post-Effective Amendment No. 65 and
	1940 Act File No. 811-23305, Amendment No. 67 (collectively, the “Amendment”)

Ladies and Gentlemen:

Pursuant to Section 101(a) of Regulation S-T and Rule 485(a) under the Securities Act of 1933, the aforementioned Registrant hereby submits for filing the following Amendment to the Registration Statement on Form N‑1A.

The principal purposes of this Amendment are to: (i) add one new series of the Registrant, Avantis U.S. Small Cap Equity ETF, and (ii) make certain other nonmaterial changes deemed appropriate by the Registrant.

If there are any questions or comments regarding this filing, please contact the undersigned at (816) 340-3267.

Sincerely,

/s/ Evan C. Johnson

Evan C. Johnson

Assistant Secretary