X0306 4 2018-05-24 0 0001537917 TYME TECHNOLOGIES, INC. TYME 0001710484 Biehl James C/O TYME TECHNOLOGIES, INC. 17 STATE STREET - 7TH FLOOR NEW YORK NY 10004 1 0 0 0 Director Stock Option - right to buy 2.90 2018-05-24 4 A 0 75000 0.00 A 2018-05-24 2028-05-24 Common Stock 75000 75000 D This option represents a one-time award in connection with changes made to the Company's compensation policies pursuant to its 2016 Stock Option Plan for Non-Employee Directors, as amended and restated effective May 24, 2018. This option is contingent upon stockholder approval of such amended and restated plan and will be void and no longer exercisable if such approval is not received. /s/ James Biehl 2018-05-29