144 0001786966 XXXXXXXX LIVE 0001710072 Edgewise Therapeutics, Inc. 001-40236 1715 38th Street Boulder Boulder CO 80301 720-262-7002 Badreddin Edris Director Common J.P. Morgan Securities LLC

270 Park Avenue 10th floor New York NY 10017

115471 3353279 105868434 01/21/2026 Nasdaq Common 01/21/2026 Stock Option Exercise Issuer N 115471 01/21/2026 Cash Y 01/21/2026 09/24/2025 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Badreddin Edris.