144 0001644087 XXXXXXXX LIVE 0001710072 EDGEWISE THERAPEUTICS INC 001-40236 1715 38th Street Boulder CO 80301 7202627002 JOANNE DONOVAN Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

71588 2265760.20 107270521 03/27/2026 NASDAQ Common 03/27/2026 Exercise of Stock Options Issuer N 50000 03/27/2026 Cash Common 05/15/2022 Employee Stock Purchase Plan Issuer N 9623 05/15/2022 Cash Common 05/01/2024 Restricted Stock Units Issuer N 11965 05/01/2024 N/A Y The 50,000 securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. The 9,623 securities to be sold were acquired upon the vesting of employee stock purchase plan during the period of 5/15/2022 through 11/15/2024. The 11,965 securities to be sold were acquired upon the vesting of restricted stock units on 05/01/2024 and 05/01/2025. 03/27/2026 12/26/2025 /s/ Joanne Donovan