<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001709954</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001770069</issuerCik>
<issuerName>MapLight Therapeutics, Inc.</issuerName>
<secFileNumber>001-42914</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">800 Chesapeake Drive</street1>
<city xmlns="http://www.sec.gov/edgar/common">Redwood City</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">94063</zipCode>
</issuerAddress>
<issuerContactPhone>(617)-984-6300</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jonathan Gillis</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>MapLight voting common stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley Smith Barney LLC</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">1 New York Plaza</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">8th Floor</street2>
<city xmlns="http://www.sec.gov/edgar/common">New York</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10004</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>4000</noOfUnitsSold>
<aggregateMarketValue>108080.00</aggregateMarketValue>
<noOfUnitsOutstanding>42436326</noOfUnitsOutstanding>
<approxSaleDate>04/15/2026</approxSaleDate>
<securitiesExchangeName>Nasdaq</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>MapLight voting common stock</securitiesClassTitle>
<acquiredDate>04/15/2026</acquiredDate>
<natureOfAcquisitionTransaction>Restricted stock unit settlement</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>MapLight Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>7305</amountOfSecuritiesAcquired>
<paymentDate>04/15/2026</paymentDate>
<natureOfPayment>Vested grant settled in stock; consideration was Reporting Person's continued service as an employee of the Issuer.</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>Shares to be sold solely to satisfy tax-withholding obligations in connection with restricted stock unit vesting.</remarks>
<noticeSignature>
<noticeDate>04/15/2026</noticeDate>
<signature>/s/ Jonathan Gillis</signature>
</noticeSignature>
</formData>
</edgarSubmission>
