CONDENSED CONSOLIDATED STATEMENTS STOCKHOLDERS EQUITY - USD ($) $ in Thousands	Common stock	Additional paid-in capital	Accumulated other comprehensive income	Accumulated deficit	Total
Balances at Beginning of period (in shares) at Dec. 31, 2020	81,053,651
Balances at Beginning of period at Dec. 31, 2020	$ 81	$ 621,946	$ 4	$ (480,471)	$ 141,560
Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs of $800	$ 7	187,193			187,200
Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs (in shares)	6,896,552
Issuance of common stock upon exercise of stock options	$ 1	5,907			5,908
Issuance of common stock upon exercise of stock options (in shares)	1,237,324
Stock-based compensation expense		8,642			8,642
Unrealized gains (losses) on investments			3		3
Net loss				(42,330)	(42,330)
Balances at End of period (in shares) at Mar. 31, 2021	89,187,527
Balances at End of period at Mar. 31, 2021	$ 89	823,688	7	(522,801)	300,983
Balances at Beginning of period (in shares) at Dec. 31, 2020	81,053,651
Balances at Beginning of period at Dec. 31, 2020	$ 81	621,946	4	(480,471)	141,560
Net loss					(196,500)
Balances at End of period (in shares) at Dec. 31, 2021	90,063,770
Balances at End of period at Dec. 31, 2021	$ 90	855,710		(677,018)	178,782
Issuance of common stock upon exercise of stock options		76			76
Issuance of common stock upon exercise of stock options (in shares)	18,228
Vesting of restricted stock units	104,628
Stock-based compensation expense		8,260			8,260
Unrealized gains (losses) on investments			(57)		(57)
Net loss				(52,412)	(52,412)
Balances at End of period (in shares) at Mar. 31, 2022	90,186,626
Balances at End of period at Mar. 31, 2022	$ 90	$ 864,046	$ (57)	$ (729,430)	$ 134,649