<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001709024</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000744218</issuerCik>
      <issuerName>Celldex Therapeutics, Inc.</issuerName>
      <secFileNumber>000-15006</secFileNumber>
      <issuerAddress>
        <com:street1>PERRYVILLE III, 53 FRONTAGE ROAD</com:street1>
        <com:street2>SUITE 220</com:street2>
        <com:city>HAMPTON</com:city>
        <com:stateOrCountry>NJ</com:stateOrCountry>
        <com:zipCode>08827</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>908-200-7500</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Martin Samuel Bates</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Services</name>
        <address>
          <com:street1>200 W Civic Center Dr - 4th Floor</com:street1>
          <com:city>SANDY</com:city>
          <com:stateOrCountry>UT</com:stateOrCountry>
          <com:zipCode>84070</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>17172</noOfUnitsSold>
      <aggregateMarketValue>583848.00</aggregateMarketValue>
      <noOfUnitsOutstanding>65900000</noOfUnitsOutstanding>
      <approxSaleDate>06/14/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>06/14/2024</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK OPTION EXERCISE</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6040</amountOfSecuritiesAcquired>
      <paymentDate>06/14/2024</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>08/10/2021</acquiredDate>
      <natureOfAcquisitionTransaction>EXERCISED SHARES</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11132</amountOfSecuritiesAcquired>
      <paymentDate>08/10/2021</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SAMUEL MARTIN</name>
        <address>
          <com:street1>PERRYVILLE III, 53 FRONTAGE RD STE 220</com:street1>
          <com:city>HAMPTON</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>08827</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>STOCK OPTION EXERCISE</securitiesClassTitle>
      <saleDate>05/30/2024</saleDate>
      <amountOfSecuritiesSold>25000</amountOfSecuritiesSold>
      <grossProceeds>850639.98</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SAMUEL MARTIN</name>
        <address>
          <com:street1>PERRYVILLE III, 53 FRONTAGE RD STE 220,</com:street1>
          <com:city>HAMPTON</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>08827</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ESPP</securitiesClassTitle>
      <saleDate>05/30/2024</saleDate>
      <amountOfSecuritiesSold>985</amountOfSecuritiesSold>
      <grossProceeds>33645.74</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>SAMUEL MARTIN</name>
        <address>
          <com:street1>PERRYVILLE III, 53 FRONTAGE RD STE 220,,</com:street1>
          <com:city>HAMPTON</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>08827</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>EXERCISED SHARES</securitiesClassTitle>
      <saleDate>05/30/2024</saleDate>
      <amountOfSecuritiesSold>4265</amountOfSecuritiesSold>
      <grossProceeds>145415.13</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/14/2024</noticeDate>
      <signature>/s/ Samuel Bates Martin</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
