Exhibit 99.1
CORPORATE PRESENTATION MARCH 2024
Important Notice and Disclaimer This presentation has been prepared by InflaRx
N.V. (“InflaRx” or the “Company”). This presentation is made for informational purposes only and does not constitute an offer to sell or a solicitation of an offer to buy securities. This presentation may not be relied upon in connection with
the purchase or sale of any security and should not be construed as investment advice. Forward-Looking Statements This press release contains forward-looking statements. All statements other than statements of historical fact are
forward-looking statements, which are often indicated by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “estimate,” “believe,” “predict,” “potential” or “continue,” among others.
Forward-looking statements appear in a number of places throughout this release and may include statements regarding our intentions, beliefs, projections, outlook, analyses and current expectations concerning, among other things, the
receptiveness of GOHIBIC (vilobelimab) as a treatment for COVID-19 by COVID-19 patients and U.S. hospitals and related treatment recommendations by medical/healthcare institutes and other third-party organizations, our ability to successfully
commercialize and the receptiveness of GOHIBIC (vilobelimab) as a treatment for COVID-19 by COVID-19 patients and U.S. hospitals or our other product candidates; our expectations regarding the size of the patient populations for, market
opportunity for, coverage and reimbursement for, estimated returns and return accruals for, and clinical utility of GOHIBIC (vilobelimab) in its approved or authorized indication or for vilobelimab and any other product candidates, under an EUA
and in the future if approved for commercial use in the U.S. or elsewhere; our ability to successfully implement The InflaRx Commitment Program, the success of our future clinical trials for vilobelimab’s treatment of COVID-19 and other
debilitating or life-threatening inflammatory indications, including PG, and any other product candidates, including INF904, and whether such clinical results will reflect results seen in previously conducted pre-clinical studies and clinical
trials; the timing, progress and results of pre-clinical studies and clinical trials of our product candidates and statements regarding the timing of initiation and completion of studies or trials and related preparatory work, the period during
which the results of the trials will become available, the costs of such trials and our research and development programs generally; our interactions with regulators regarding the results of clinical trials and potential regulatory approval
pathways, including related to our MAA submission for vilobelimab and our biologics license application submission for GOHIBIC (vilobelimab), and our ability to obtain and maintain full regulatory approval of vilobelimab or GOHIBIC
(vilobelimab) for any indication; whether the FDA, the EMA or any comparable foreign regulatory authority will accept or agree with the number, design, size, conduct or implementation of our clinical trials, including any proposed primary or
secondary endpoints for such trials; our expectations regarding the scope of any approved indication for vilobelimab; our ability to leverage our proprietary anti-C5a and C5aR technologies to discover and develop therapies to treat
complement-mediated autoimmune and inflammatory diseases; our ability to protect, maintain and enforce our intellectual property protection for vilobelimab and any other product candidates, and the scope of such protection; our manufacturing
capabilities and strategy, including the scalability and cost of our manufacturing methods and processes and the optimization of our manufacturing methods and processes, and our ability to continue to rely on our existing third-party
manufacturers and our ability to engage additional third-party manufacturers for our planned future clinical trials and for commercial supply of vilobelimab and for the finished product GOHIBIC (vilobelimab); our estimates of our expenses,
ongoing losses, future revenue, capital requirements and our needs for or ability to obtain additional financing; our ability to defend against liability claims resulting from the testing of our product candidates in the clinic or, if approved,
any commercial sales; if any of our product candidates obtain regulatory approval, our ability to comply with and satisfy ongoing obligations and continued regulatory overview; our ability to comply with enacted and future legislation in
seeking marketing approval and commercialization; our future growth and ability to compete, which depends on our retaining key personnel and recruiting additional qualified personnel; and our competitive position and the development of and
projections relating to our competitors in the development of C5a and C5aR inhibitors or our industry; and the risks, uncertainties and other factors described under the heading “Risk Factors” in our periodic filings with the SEC. These
statements speak only as of the date of this press release and involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future
results, performance or achievements expressed or implied by the forward-looking statements. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no
obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.
Important Notice and Disclaimer Information and Sources Certain information
contained in this presentation relates to or is based on studies, publications, surveys and other data obtained from third-party sources and InflaRx’s own internal estimates and research. While InflaRx believes these third-party sources to be
reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, all of the
market data included in this presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions. Further, while we believe our own internal research is reliable,
such research has not been verified by any independent source. Avacopan Data We have not conducted a head-to-head comparison of Avacopan to INF904 in a clinical trial but have compared the published data for Avacopan to data from our Phase 1
clinical trial of INF904. For the purpose of conducting pre-clinical studies (hamster neutropenia study), we synthesized Avacopan and did a side-by-side comparison. While we believe this comparison to Avacopan to be useful and appropriate, the
value of this and other comparisons to Avacopan in this presentation may be limited because they are not derived from a head-to-head trial and they are from trials that were conducted under different protocols at different sites and at
different times. Without head-to-head data, we are unable to make comparative claims between INF904 and Avacopan. About InflaRx InflaRx GmbH (Germany) and InflaRx Pharmaceuticals Inc. (USA) are wholly owned subsidiaries of InflaRx N.V.
(together, “InflaRx”). InflaRx (Nasdaq: IFRX) is a biotechnology company pioneering anti-inflammatory therapeutics by applying its proprietary anti-C5a and anti-C5aR technologies to discover, develop and commercialize first-in-class, potent
and specific inhibitors of the complement activation factor C5a and its receptor C5aR. C5a is a powerful inflammatory mediator involved in the progression of a wide variety of inflammatory diseases. InflaRx’s lead product candidate,
vilobelimab, is a novel, intravenously delivered, first-in-class, anti-C5a monoclonal antibody that selectively binds to free C5a and has demonstrated disease-modifying clinical activity and tolerability in multiple clinical studies in
different indications. InflaRx was founded in 2007, and the group has offices and subsidiaries in Jena and Munich, Germany, as well as Ann Arbor, MI, USA. For further information, please visit www.inflarx.com.
Harnessing C5a/C5aR for Controlling Inflammation in the I&I Space InflaRx
Highlights Uniquely targeting complement C5a/C5aR, a validated mechanism and critical part of the inflammation cascade with: First-in-class and highly potent anti-C5a monoclonal antibody (vilobelimab + second generation IFX-2) Best-in-class
potential oral C5aR inhibitor INF904: Addressing limitations of marketed comparator (clearly differentiated plasma PK profile and inhibitory potential in phase I study) Pipeline-in-a-drug with potential to address several large markets in
immuno-dermatology and broader I&I A targeted development focus on immuno-dermatology where InflaRx can drive pipeline value in larger markets and has strong core IP and medical use IP coverage Vilobelimab in late-stage development for PG
an unmet need with no approved drug in the US or Europe INF904 to initially demonstrate pipeline-in-a-drug potential in large markets of CSU and HS; expected to start Phase II development in 2024 Large upside potential in additional
indications in I&I for proprietary drugs with options for collaborations Strong balance sheet with enough cash to fund operations into at least 2026 and advance programs toward next milestones Team with proven track record of delivering
clinical and regulatory successes CSU [chronic spontaneous urticaria. HS [hidradenitis suppurativa]. PG [pyoderma gangrenosum]. I&I [inflammation and immunology]. Page 4
Significant Opportunity in Immuno-Dermatology Page 5 Potential to target several
attractive, billion-dollar+ commercial markets InflaRx has identified unmet medical needs that INF904 could strongly address Strong rationale for the role of C5a/C5aR based on mechanism of action, pre-clinical and clinical data Established
endpoints with the ability of INF904 to potentially achieve a clinical edge and prove to be a differentiated competitor INF904 is an oral drug with no known safety concerns and potential broad therapeutic index As a C5aR antagonist, INF904
acts on a differentiated pathway with a MoA not currently addressed by any other treatment approaches in the immuno-dermatology field Established network of experts and in-house trial expertise Strong IP coverage for C5aR inhibition in
certain immuno-dermatological diseases Why Immuno-Dermatology
Key initial development focus and area to demonstrate potential of
INF904 Potential for future development or development in collaboration with a partner Immuno-dermatology Neurology Nephrology & Hematology Chronic spontaneous urticaria (CSU) Hidradenitis suppurativa (HS) others Chronic
inflammatory demyelinating polyneuropathy (CIDP) Dermatomyositis Anti-C3 glomerulopathy (C3G) Atypical haemolytic uraemia syndrome (aHUS) Immunoglobulin A nephropathy (IgAN) ANCA-associated vasculitis (AAV) Page 6 Focus INF904 on
Immuno-Dermatology: I&I Pipeline-in-a-Drug Potential
Page 7 Late-Stage Pipeline Targets Multiple Sizable Markets vilobelimab C5a
Inhibitor IFX002 C5a Inhibitor INF904 Oral C5aR Inhibitor IMMUNO-DERMATOLOGY vilobelimab C5a Inhibitor OTHER INF904 Oral C5aR Inhibitor chronic spontaneous urticaria Phase IIa “basket study” anticipated by YE 2024 Data
anticipated in 2025 Indications PreClin Phase I Phase II Phase III MARKET STATUS & Milestones pyoderma gangrenosum Enrollment ongoing Interim analysis for adaptation and futility anticipated in 2025 critical COVID-19 broader
ARDS US EUA granted; EU MAA under review ARDS “Phase III ready” hidradenitis suppurativa Phase IIa “basket study” anticipated by YE 2024 Data anticipated in 2025 other immuno-dermatology Additional indications in
immuno-dermatology vilobelimab life-cycle approach For optimized use in chronic inflammatory indications various Additional chronic indications in I&I including neurology, nephrology and hematology and others
Vilobelimab [C5a monoclonal antibody] INF904 [oral C5aR inhibitor] C5a/C5aR: A
Strategic Position in the Inflammatory Cascade
Anaphylatoxin C5a is upstream of the cytokine network Boosting effect on various
pro-inflammatory cytokines IL-17, IL-6, IL-8, IL-1 and others Strong activator of neutrophils and macrophages Chemotaxis of neutrophils O2 radical generation + granular enzyme release NETosis (neutrophil extracellular traps) Essential
role in many inflammatory conditions Acute and chronic inflammation and other conditions Over 6,000 publications on role in numerous diseases C5a/C5aR are Validated Targets Promoting Inflammation Page 9 C5a strong amplifierof
inflammation C5aR expressed on many immune cells and upregulated in many tissues under disease conditions Targeting strong pro-inflammatory mechanisms vilobelimab intravenous mAB INF904 oral small molecule Targeting C5 (e.g. marketed C5
blockers) does not prevent enzymatic C5a formation, but only complement pathway mediated cleavage (classic, lectin, alternative) not suitable for tightly controlling C5a/C5aR1-driven inflammation C5
Vilobelimab for Ulcerative Pyoderma Gangrenosum (PG)
Highly selective anti-C5a mAB Blocks C5a biological effects up to 100% in human
blood Leaves MAC formation intact Fast binding / high affinity to the newly discovered epitope Commercially validated / available under Emergency Use Authorization in certain severely ill COVID-19 patients Vilobelimab: A First-in-Class
Anti-C5a Monoclonal Antibody Page 11 new epitope Vilobelimab Key Features Development Areas in Acute and Sub-Acute Inflammation As a fast acting highly specific monoclonal antibody infused, vilobelimab delivers: Strong and immediate C5a
inhibition in blood Fast onset of inhibition of neutrophil activation in human blood Potential disease modifying activity for diseases in which C5a signaling may play a key role
PG: An Autoimmune Condition With High Unmet Need Page 12 PG Overview and Unmet
Need Clinical features PG is a rare but potentially life-threatening skin disorder that can lead to chronic, difficult-to-treat wounds Patients frequently suffer from other autoimmune disorders, e.g. ulcerative colitis, rheumatoid arthritis
and hematological diseases Patients suffer from severe pain, long healing times and frequent relapses Incidence and market potential Rare – estimated that up to 50,000 patients in the US and Europe are affected Significant market potential
– premium pricing expected based on performed market study Current treatment and medical need No drugs currently approved in the US or EU For less severe cases, topical or intralesional treatments can be used, including topical steroids Use
of systemic immunosuppression in rapidly progressing cases Mixed reports about efficacy; long treatment durations and relapses are frequently seen Strong rationale for treatment with vilobelimab: PG associated with neutrophilic skin
infiltration in affected areas and lesions, potentially triggered by C5a
C5a Levels in PG Wound Fluid Correlate With NETosis The etiology of PG is
believed to be linked to the dysregulation of the immune system, specifically, altered neutrophil function Evidence suggest that complement activation and C5a play an important role in the disease development: High C5a levels were detected in
the wound fluids from PG patients C5a levels correlated well with elastase levels in wound fluids, a NETosis marker C5a/C5aR axis activation may be a key driver for NETosis in PG C5a Induces NETosis in Control Neutrophils
PG Pathogenesis: Potential Role of the C5a/C5aR Axis Page 13 Con C5a (20 nM; 1hr) Extracellular DNA Staining Wang et al 2024. J invest Derm. 144; TW = Trauma Wound
PG Phase IIa Showed No Safety or Tolerability Concerns and Dose-Dependent Drug
Activity Page 14 Clinical Response High-dose group showed highest rate of target ulcer closure and clinical remission (86%) Out of 17 evaluable patients at end of treatment visit or day of last drug administration Clinical remission (PGA
≤ 1) reported in 9 patients (53%) Clinical response (PGA ≤ 3) reported in 1 additional patient (6%) Slight improvement (PGA = 4) reported in 7 patients (41%) Safety No infusion-related reactions observed For 2 patients, related SAEs were
reported Erysipelas leading to hospitalization (judged as non-related by sponsor) Rash due to delayed hypersensitivity reaction Observed AE profile in line with patients’ underlying diseases No dose-related AEs detected Phase III
Initiated Based on Feedback From FDA Orphan Drug and Fast Track Status US FDA Orphan Drug Status EMA
PG Study Phase IIa – Treatment Examples Patient Case Studies Page 15 Target
Ulcer Developed While on Adalimumab MH: PG since August 2020, Psoriasis since 2017 Previous PG medication: None Cohort 3: 2400 mg Q2W up to Day 85 -> exclusion after 9 doses due to delayed availability of pos. baseline TB testing result
(no TB activation) Concomitant medication: Adalimumab for psoriasis 40mg q2w since 2017 Target Ulcer Reappeared MH: PG since 2019, Hypertension since 1998 Previous PG medication: Methylprednisolone only in Jun 2019, Dapsone Jun 2019 - Aug
2020, Cyclosporine Oct 2019 - Aug 2020 -> ulcer healed and reappeared after discontinuation of immunosuppressants Cohort 2: 1600 mg Q2W, individual up-titration to 2400 mg at D57, treatment completed Concomitant medication: Prednisone 10
mg for PG since October ‘20 Day 89 PGA = 1 Area: not yet available Baseline Area: 1136 mm2 Day 85 PGA = 1 Area: 0.00 mm2 Day 189 PGA = 1 Area: 0.00 mm2 Baseline Area: 3695 mm2 Day 99 PGA = 1 Area: 0.00 mm2
PG Phase III Study Design: Interim Analysis Expected in 2025 Page 16 Treatment:
26 Weeks Follow up: 12 Weeks Safety Follow Up Prednisone tapered off Prednisone tapered off Randomization vilobelimab 2400 mg Q2W (13 doses) EOT (W 26) Safety Follow Up Patient Level Stopping Criteria progression (any time) or no
improvement at defined time points 22 20 18 16 14 12 10 0 2 4 6 8 placebo Q2W (13 doses) 24 Week Dosing 26 Arm 1 Arm 2 Arm 1 Arm 2 n approx. = 15 n approx. = 15 Interim Analysis*set rules for size adjustment or
futility stop by IDMC Total number of patients to be adjusted between 50 – 100** Primary endpoint: complete target ulcer closure Adaptive Design * Blinded except for independent data safety monitoring committee / **Adjustment of
randomization ratio to 2:1 (Arm 1 to Arm 2) after blinded interim analysis Screening
INF904: An Oral Highly Selective C5aR Inhibitor With Best-in-Class Potential
INF904: Oral C5aR Antagonist With Best-in-Class Potential Page 18 INF904 Key
Features Focusing on Immuno-Derm, Other Options Possible Favorable drug profile supported by preclinical studies and data reported from InflaRx’s Phase I SAD and MAD trials Phase I PK/PD profile that could open significant market
opportunities for the C5aR oral inhibitor class well-tolerated and no safety signals over entire tested dose range (no reported SAEs, AE lower than in placebo group) evidence of broad therapeutic index, BID and QD dosing Has ~3-fold higher
Cmax and ~10-fold higher AUClast versus published avacopan data, for comparable doses (3, 10, 30 mg) Significantly increased blocking activity of C5a-induced neutrophil activation than avacopan’s published data Higher plasma exposures and
>90% blocking of C5a activity Achieves therapeutic exposures fast which may be needed to successfully treat chronic immuno-inflammatory diseases Potential for broad range of dosing Higher drug strength with reduced capsule intake
potential Much weaker inhibitor of CYP3A4/5 than avacopan Strong IP position, with US patent issued in October 2021 Immuno Dermatology Neuro Inflammation Others Nephrology Hematology As a small molecule orally available C5aR
inhibitor, INF904 has the potential to deliver… Favorable tissue penetration and plasma concentrations Sustained long-term control over C5a/C5aR activation in a variety of chronic inflammatory diseases Convenient oral administration …to
multiple large commercial markets
INF904: Oral C5aR Antagonist With Best-in-Class PotentialINF904 Has Double the
Inhibitory Effect in Vivo in a Pre-clinical Model Compared to Avacopan Page 19 Inhibition of in vivo neutrophil activation by INF904 compared to avacopan-like molecule* Experiment: Challenge of rodents with C5a leads to neutrophil activation
and consequent adherence (sticking) of neutrophils to the endothelial cell wall of vessels = mimicking a neutropenia (vehicle). This effect can be completely inhibited when C5aR activation is blocked. Note: INF904 dosing within this experiment
exerts an approximately 4.5-fold higher plasma level 8 h after dosing when compared to the identical dosing with avacopan* Plasma Concentration Sampled at 8 hours: INF904 = 538 ng/mL Avacopan-like molecule = 119 ng/mL INF904 doubled the
in vivo inhibitory effect at comparable dose when tested head-to-head with avacopan. The strongly improved PK features of INF904 (plasma exposure) may drive the ability to increase efficacy in vivo. Source: InflaRx data on file. *Avacopan
synthesized based on the published structure and publicly available data.
INF904: Oral C5aR Antagonist With Best-in-Class PotentialPK Results From Single
Ascending Dose (SAD) Phase 1 Page 20 Parameter Unit Dose INF904 Avacopan* AUCinf h.ng/ml 3 mg 285 25 10 mg 1264 130 30 mg 5956 628 AUClast h.ng/ml 3 mg 254 23 10 mg 1117 122 30 mg 5197 557 Cmax ng/ml 3
mg 21.5 9 10 mg 74.8 25 30 mg 289 79 tmax hr 3 mg 3.5 1.2 10 mg 4 1.7 30 mg 5.01 1.7 INF904 240mg INF904 60mg INF904 30mg INF904 120mg Avacopan* 30mg INF904 240mg INF904 60mg INF904 30mg INF904 120mg Source: Bekker
et al. 2016, PLoS One; 11(10): e0164646 *Please note: Avacopan data taken from Bekker et al. 2016, PLoS One; 11(10): e0164646 are superimposed in graph for orientation. Avacopan was not included as a comparator in INF904 Phase I study. In
comparison to published data for avacopan INF904 is approximately 3-fold higher in Cmax and 10-fold higher in systemic exposure (AUClast) for comparable doses (3, 10, 30 mg)
PD MAD results confirm strong >90% C5a inhibition at C5a levels found in human
diseases – this is clearly differentiated from reported avacopan results which have shown approximately 50% inhibition at a lower challenge of 10nM C5a (7 day dosing – trough)** Upon stimulation with 12.6 nM rhC5a (levels observed in disease
state) 24 h 144 h (Day 6) 168 h (Day 7) 312 h (Day 13) 336 h (Day 14) C5a (nM) 30QD 30BID 90BID 30QD 30BID 90BID 30QD 30BID 90BID 30QD 30BID 90BID 30QD 30BID 90BID Blockade (%)
80 94 90 93 95 94 95 97 97 96 92 97 90 95 97 EC50 (nM) 35.6 106.2 145.6 52.4 134.7 160 74.2 149.0 268.2 92.4 126.3 465.7 94.6 110.9 238 INF904: Oral C5aR Antagonist With Best-in-Class PotentialC5a-Mediated CD11b
Upregulation on Neutrophils Ex Vivo up to 14-day Dosing Page 21 *EC50 (nM) is the half maximal effective C5a concentration ** Bekker et al. 2016, PLoSOne; 11(10): e0164646 INF904: 30 mg QD INF904: 30 mg BID INF904: 90 mg BID
Page 22 Investing Into INF904 Development Phase IIa Expected to Begin by EOY
2024 Initial Phase IIa – demonstrating pipeline-in-a-drug potential of INF904 Open-label PK / PD “basket study” to explore initial efficacy signals 4-week treatment period in 2 immuno-derm indications CSU and HS with established
endpoints Safety and PK / PD assessment planned for at least 3 different doses Expected catalysts Phase IIa expected to begin by EOY 2024 Phase IIa data anticipated in 2025 Larger and longer-term Phase IIb study expected to begin in 2025
INF904 for Chronic Spontaneous Urticaria (CSU)
A Strong Rationale for Developing INF904 in CSU C5aR Signaling is Involved in
Histamine Release in an IgE Independent Manner Increasing scientific evidence suggests that C5aR signaling is involved in histamine release from mast cells and basophils in CSU in an IgE independent manner. This mechanism may play an
important role for both described endotypes in CSU: Type I (IgE mediated) and Type IIb (IgG autoantibody mediated) Despite availability of current treatment options such as anti-histamines and anti-IgE therapy, approximately 30-60%* of
these patients are estimated to remain non-responsive or symptomatic. INF904 could be a convenient oral therapeutic option for those underserved with current therapies. CSU market potential is estimated to exceed $3 Bn by 2032** * Metz et
al, Clin Rev Allergy Immunol. 2020; 59(1): 38–45. ** GlobalData and Leerink analyst report Page 24
Chronic Spontaneous Urticaria (CSU) CSU Overview and Unmet Need Clinical
features An immune-mediated chronic inflammatory skin disorder, with dysregulated inflammatory cascades that leave patients predisposed to symptom development: debilitating and intensely itchy hives / wheals for > 6 weeks and often
associated with angioedema Burden of disease is high and impacts sleep, mental health, QoL and productivity due to absences from school and work Co-morbidities include atopic disorders, depression, autoimmune and thyroid
disorders Epidemiology Estimated prevalence is around 1% of the general population 20% of this population experiences symptoms for more than 5 years 20 to 40 year-olds are most affected, with women impacted 2x more than men Current
treatment and medical need Therapies such as 2nd-generation antihistamines are not effective in a significant number of patients Options such as anti Ig-E therapy and immunosuppressants also do not adequately serve the CSU population Page
25
CSU Endotypes - Type 1 Auto-Allergens and Type IIb Autoimmunity Two major
endotypes of CSU described as activation of mast cells include: Maurer et al. Clinical reviews in allergy and clinical immunology. 2022. 1 2 Type I autoallergens (IgE mediated) Type IIb autoimmunity (IgG mediated; ~30% of CSU) C5a is
activated by the binding of IgG-anti-FcεRI or IgG-anti-IgE to FcεRI on mast cells and basophils C5aR signaling is suggested to be involved in both, type I and type IIb endotypes 1 2 Page 26
C5a in CSU and its Role in IgE-Independent Histamine Release Page 27 CSU
patients show evidence of complement activation in the skin CSU patients have elevated C5a levels 46.9 ng/ml 20.1 ng/ml N=95 N=42 p = 0.004 C4d staining in skin biopsy C5a (ng/mL) C5a induces histamine release from basophils in a
dose-dependent manner Histamine release (percentage) from donor basophils stimulated with increasing levels of C5a C5a mediated histamine release is independent of the IgE pathway C5a stimulation of histamine releases is not affected by IgE
pathway / SYK inhibitor GSK2646264 Human Skin ex vivo Model: microdialysis tubing into the ex vivo human skin with 1nM C5a Bhatia et al. 2024 Asia Pacific Allergy 14 ; Aghdam et al. 2021 Clin Transl Allergy. 11 Kikuchi, 2002 J Allergy
Clin Immunol:109 Molina et al; 2019 Br J Pharmacol: 176
C5a-Induced Histamine Release is Important for Both, IgE Dependent Pathway and
IgE Independent Pathway C5a/C5aR Contributes to Histamine Release in an IgE Independent Manner Anti-IgE Stimulus pos. (>20% HR) Anti-IgE Stimulus neg. C5a generation in CSU may be amplified by the activation of the coagulation pathways
(tissue factor [TF] release) in addition to the auto-antibody trigger Basophils isolated from CSU patients C5a stimulation leads to dose-dependent histamine release Basophils isolated from CSU patients C5a stimulation leads to
dose-dependent histamine release Matsubara et al. Front Immunol 2022, 13. Page 28
INF904 Development in CSU Page 29 Conclusion: C5aR signaling is involved in
histamine release from mast cells / basophils in CSU This C5a-mediated histamine release is independent of the IgE pathway and has been suggested to play a role in both subtypes of CSU C5aR inhibition represents a novel mechanism of action
(MoA) to address an unmet medical need in CSU INF904 as an oral potent C5aR inhibitor is ideally positioned for development in CSU
INF904 for Hidradenitis Suppurativa (HS)
A Strong Rationale for Developing INF904 in HS New Mechanisms are Needed New
mechanisms are needed to address the disease more completely E.g. moderate to severe patients with active draining disease currently have limited approved treatment options which have proven to be effective for them and response to treatment
with approved anti-TNF-alpha or anti-IL17 agents is known to wane over time in a significant number of cases HS patients have a preference for oral medications over injections (and surgical incisions)* INF904 is an oral C5aR inhibitor
with: A mechanism of action which inhibits the known C5a induced effects on neutrophil activation and tissue accumulation of immune cells including induction of NETosis – mechanisms which have been suggested to be involved in HS progression
and specifically in HS lesion formation Clinical evidence existing that blocking the C5a/C5aR pathway reduces lesion counts in HS A favorable PK/PD profile with a broad dose range for systemic exposure in patients HS market potential is
attractive, with a market size estimated with >$3.9 Bn by 2032** * Willems, D., Hinzpeter, EL., Van der Zee, H.H. et al. Patient 16, 153–164 (2023) ** GlobalData and Leerink / Guggenheim analyst reports Page 31
Hidradenitis Suppurativa (HS) HS Overview and Unmet Need Clinical features A
chronic, recurring, debilitating neutrophil-driven inflammatory disease, that can persist for years Characterized by abscesses, nodules and draining tunnels (dTs) with purulent or bloodstained discharge, that can flare and cause
scarring Predilection for intertriginous sites such as axillae, groin, buttocks and inframammary areas Associated with severe bacterial infections, tremendous QoL impairment and functional disability Epidemiology Prevalence in the US and EU
is estimated to be 0.7% - 1.2% Though estimates vary widely, we estimate there are clearly more than 200,000 moderate to severe HS patients in the US alone Current treatment and medical need Current treatments including pain management,
antibiotics, corticosteroids and biologics Current approved therapies have shown a waning of effect in a significant number of patients over time In addition, high-unmet medical need exists in affected patients with active draining
disease Page 32
An Important Role for C5a/C5aR is Recognized in HS Pathogenesis van Straalen KR
Front. Immunol. 13:953674.doi: 10.3389/fimmu.2022.953674 Mechanism in HS development: Follicular occlusion of the folliculo-pilosebaceous unit, followed by follicular rupture, leading to immune responses which involve complement activation
including C5a/C5aR engagement, resulting in the development of clinical HS lesion Page 33
Page 34 Strong Rationale for Developing an Anti-C5a/C5aR in HS HS Patients Have
Elevated C5a, a Major Neutrophil Activator That Can Be Blocked by an Anti-C5a/C5aR Kanni et al, 2018 HS patients have significant complement activation with elevated C5a levels C5a/C5aR activation is a key neutrophil activator in HS patient
plasma Guo et al. 2019 Aug. US Patent No. 10,376,595 Source: InflaRx in house data on file HS patient plasma strongly provokes neutrophil activation in healthy donor blood: this effect could be completely blocked by the addition
of: Vilobelimab (anti-C5a antibody) and INF904 (anti-C5aR inhibitor) Concentrations of C5a in the plasma of 14 healthy controls and of 54 patients with HS. P-values symbolize significant differences between patients and controls.
Enhanced C5aR Staining in Biopsies From HS Patients at All Disease Stages Page
35 C5aR1 Staining HF: Hair follicles S: Suppurative Hurley stage I patient with extensive deep dermal and subcutaneous suppurative abscessing inflammation, surrounding hair follicles with hyperkeratosis. C5aR1 staining positive –
neutrophils T: Tunnel R: Tunnel rupture PEH: Psoriasiform epidermal hyperplasia Hurley stage II patient with tunnel formation and tunnel rupture area with epithelium surrounded by sheets of neutrophils. C5aR1 staining positive –
neutrophils T: Tunnel G: Granuloma F: Fibrosis Hurley stage III patient with tunnel formation and surrounding granulomatous inflammation with foreign body giant cells. C5aR1 staining positive – neutrophils, histiocytes and giant
cells H&E Staining Van Straalen et al. 2022. Front Immunol 21.
Clinical Evidence for the Role of C5a/C5aR Signaling in HS Page 36 Vilobelimab
(anti-C5a mAb) SHINE Phase IIb study in moderate-severe HS patients resulted in various signals of efficacy for high dose treatment group (1200mg EOW) including an overall inflammatory lesion reduction * In SHINE, dT reduction was higher in
patients with tightly controlled C5a levels * Key learning from SHINE: a higher dose of vilobelimab was needed to adequately control C5a/C5aR signaling and increase efficacy in lesion reduction Avacopan (oral C5aR inhibitor) At standard dose
of 30 mg BID, a p-value positive efficacy signal was detected in severe HS patients (Hurley III) on HiSCR with clear separation from placebo group emerging at week 12 ** Of note: in ANCA vasculitis patients steady-state levels of avacopan at
30 mg BID were only reported to be achieved at approx. 3 mths *** 30 mg BID dosing regimen may have been too low for adequate HS treatment and late accumulation of avacopan may have prevented earlier onset of efficacy * InflaRx data on
file ** Data from Chemocentryx presentation on AURORA trial results, October 28, 2020: note: overall results were not stat. significant for HiSCR in all moderate to severe HS patients (primary endpoint ) *** Data from avacopan NDA filing for
ANCA-associated vasculitis
Avacopan Data in Phase II Clinical Trial Shows Efficacy Emerging Only at W12 Page
37 Results From Avacopan in HS Patients (Hurley III)* Avacopan’s efficacy (separation from placebo group) in HS only starts to emerge at W12 – please note: steady state reported from ANCA patients was only reached at approx. 3 months due to
prolonged drug accumulation (x4) Avacopan’s 30mg BID dosing regimen may be too low to show adequate clinical efficacy in HS *Data from Chemocentryx presentation on AURORA trial results, October 28, 2020: note: overall results were not stat.
significant for HiSCR in all moderate to severe HS patients (primary endpoint)
Avacopan Data in ANCA Patients Shows Steady State Reached by 13 Weeks Page
38 Avacopan reported plasma trough PK data in ANCA Patients* Steady state plasma levels of avacopan 30mg BID are reached by 13 weeks and the accumulation is approximately 4-fold Mean steady state plasma exposure estimates of avacopan are:
3466 h*ng/mL for the (AUC0-12hr) in ANCA patients receiving 30 mg BID Plasma accumulation may be a prerequisite for reaching blocking activity of C5aR1 on neutrophils, to sufficiently prevent activation and migration into tissue in order to
show clinical efficacy *Data from avacopan NDA filing for ANCA-associated vasculitis: represented graphically.
Vilobelimab* and Avacopan** Provide Evidence for Efficacy in HS Patients Page
39 Conclusion: There is a strong scientific rationale for the role of C5aR in HS C5a/C5aR signaling inhibition has resulted in signals of efficacy in HS patients Tight control over C5aR signaling is required to achieve optimal efficacy –
dosing is important in HS! INF904 is ideally positioned as an oral C5aR inhibitor with optimized PK / PD profile to address an existing high unmet medical need in HS patients * Source: InflaRx data on file. ** Source: Data from Chemocentryx
presentation on AURORA trial results, October 28, 2020
Gohibic (vilobelimab) Critical COVID-19 & ARDS
Emergency Use Authorization (EUA) Granted for Gohibic Page 41 Gohibic
(vilobelimab) has not been approved, but has been authorized for emergency use by FDA under an EUA*, for the treatment of COVID-19 in hospitalized adults when initiated within 48 hours of receiving IMV**, or ECMO** MAA under review at EMA /
CHMP in Europe, discussions with US FDA ongoing related to future BLA submission Authorization granted based on results from a Phase III clinical trial in critically ill, mechanically ventilated COVID-19 patients in which Gohibic treatment
reduced mortality by 23.9% vs. placebo. Gohibic is the first authorized therapeutic targeting C5a as potential key player in the inflammatory host response Gohibic has been launched by InflaRx in the US under the EUA: Building an
experienced and highly focused commercial team and creating awareness with different healthcare players Building a robust supply chain to allow for uninterrupted supply of Gohibic to US hospitals (vilobelimab) * The emergency use of GOHIBIC
is only authorized for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of drugs and biological products during the COVID-19 pandemic under Section 564(b)(1) of the Act, 21 U.S.C. §
360bbb-3(b)(1), unless the declaration is terminated or authorization revoked sooner ** IMV = invasive mechanical ventilation, ***ECMO = extracorporal membrane oxygenation For additional and important safety information, please visit
www.gohibic.com
Email: IR@inflarx.com Tel: +49-3641-508180 Fax:
+49-3641-508181 www.inflarx.com InflaRx N.V. Winzerlaer Str. 207745 Jena, Germany