INFLARX N.V.
|
||
Date: March 24, 2022
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By:
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/s/ Niels Riedemann
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Name:
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Niels Riedemann
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|
Title:
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Chief Executive Officer
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Exhibit No.
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Description
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Press Release, dated March 24, 2022
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![]() |
|
• |
Company received corrected FDA advice letter for Phase III trial with vilobelimab in hidradenitis suppurativa
|
• |
Positive Phase IIa data reported with vilobelimab in pyoderma gangrenosum; data being presented as late-breaker oral presentation at AAD Annual Meeting
|
• |
Topline data in vilobelimab Phase III trial in severe COVID-19 expected by end of March
|
• |
Both US and EU Phase II trials with vilobelimab in AAV met their objectives
|
• |
Phase II trial with vilobelimab in cSCC enrolling with first efficacy data expected later this year
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• |
New program, INF904 oral small molecule inhibitor of C5aR, recently introduced
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• |
Year-end cash and cash equivalents of approximately €26.2 million and financial assets of approximately €84.4 million
|
![]() |
|
![]() |
|
![]() |
|
![]() |
|
![]() |
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![]() |
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in €, except for share information
|
2021
|
2020
|
2019
|
|||||||||
Operating Expenses
|
||||||||||||
Research and development expenses
|
(35,697,935
|
)
|
(25,684,140
|
)
|
(44,582,136
|
)
|
||||||
General and administrative expenses
|
(11,984,722
|
)
|
(8,467,203
|
)
|
(12,501,048
|
)
|
||||||
Total Operating Expenses
|
(47,682,657
|
)
|
(34,151,343
|
)
|
(57,083,184
|
)
|
||||||
Other income
|
54,221
|
221,748
|
400,253
|
|||||||||
Other expenses
|
(6,381
|
)
|
(13,209
|
)
|
(85,242
|
)
|
||||||
Operating Result
|
(47,634,816
|
)
|
(33,942,804
|
)
|
(56,768,173
|
)
|
||||||
Finance income
|
109,391
|
887,702
|
2,840,676
|
|||||||||
Finance expenses
|
(24,769
|
)
|
(26,000
|
)
|
(22,265
|
)
|
||||||
Foreign exchange result
|
1,964,135
|
(776,512
|
)
|
694,944
|
||||||||
Other financial result
|
(44,000
|
)
|
(126,000
|
)
|
—
|
|||||||
Income Taxes
|
—
|
—
|
—
|
|||||||||
Loss for the Period
|
(45,630,059
|
)
|
(33,983,614
|
)
|
(53,254,817
|
)
|
||||||
Share Information
|
||||||||||||
Weighted average number of shares outstanding
|
41,629,974
|
27,064,902
|
26,004,519
|
|||||||||
Loss per share (basic/diluted)
|
(1.10
|
)
|
(1.26
|
)
|
(2.05
|
)
|
||||||
Loss for the Period
|
(45,630,059
|
)
|
(33,983,614
|
)
|
(53,254,817
|
)
|
||||||
Other comprehensive income (loss) that may be re-clas-si-fied to profit or loss in subsequent periods:
|
||||||||||||
Exchange differences on translation of foreign currency
|
6,777,061
|
(5,954,019
|
)
|
2,177,033
|
||||||||
Total Comprehensive Loss
|
(38,852,998
|
)
|
(39,937,633
|
)
|
(51,077,785
|
)
|
![]() |
|
in €
|
2021
|
2020
|
||||||
ASSETS
|
||||||||
Non-current assets
|
||||||||
Property and equipment*
|
274,373
|
408,263
|
||||||
Right-of-use assets*
|
1,408,078
|
546,694
|
||||||
Intangible assets
|
235,216
|
350,183
|
||||||
Other assets
|
336,566
|
353,522
|
||||||
Financial assets
|
27,206,990
|
272,268
|
||||||
Total non-current assets
|
29,461,224
|
1,930,930
|
||||||
Current assets
|
||||||||
Current other assets*
|
10,983,458
|
3,734,700
|
||||||
Income tax receivable*
|
1,282,177
|
1,419,490
|
||||||
Financial assets
|
57,162,266
|
55,162,033
|
||||||
Cash and cash equivalents
|
26,249,995
|
25,968,681
|
||||||
Total current assets
|
95,677,896
|
86,284,904
|
||||||
TOTAL ASSETS
|
125,139,120
|
88,215,834
|
||||||
EQUITY AND LIABILITIES
|
||||||||
Equity
|
||||||||
Issued capital
|
5,304,452
|
3,387,410
|
||||||
Share premium
|
280,310,744
|
220,289,876
|
||||||
Other capital reserves
|
30,591,209
|
26,259,004
|
||||||
Accumulated deficit
|
(213,975,679
|
)
|
(168,345,620
|
)
|
||||
Other components of equity
|
3,050,270
|
(3,726,791
|
)
|
|||||
Total equity
|
105,280,996
|
77,863,880
|
||||||
Non-current liabilities
|
||||||||
Lease liabilities
|
1,066,354
|
220,525
|
||||||
Other liabilities
|
35,019
|
33,323
|
||||||
Total non-current liabilities
|
1,101,373
|
253,847
|
||||||
Current liabilities
|
||||||||
Trade and other payables
|
8,574,244
|
8,258,133
|
||||||
Liabilities from government grants received
|
8,300,000
|
—
|
||||||
Lease liabilities
|
366,171
|
338,516
|
||||||
Employee benefits
|
1,378,130
|
1,368,731
|
||||||
Other liabilities
|
138,206
|
117,727
|
||||||
Provisions
|
—
|
15,000
|
||||||
Total current liabilities
|
18,756,751
|
10,098,107
|
||||||
Total Liabilities
|
19,858,124
|
10,351,954
|
||||||
TOTAL EQUITY AND LIABILITIES
|
125,139,120
|
88,215,834
|
![]() |
|
in €
|
Issued
capital
|
Share
premium
|
Other
capital reserves
|
Accumulated deficit
|
Other
components of equity
|
Total
equity
|
||||||||||||||||||
Balance as of January 1, 2019
|
3,115,725
|
211,021,835
|
18,310,003
|
(81,107,188
|
)
|
50,196
|
151,390,571
|
|||||||||||||||||
Loss for the Period
|
—
|
—
|
—
|
(53,254,817
|
)
|
—
|
(53,254,817
|
)
|
||||||||||||||||
Exchange differences on
translation of foreign currency
|
—
|
—
|
—
|
—
|
2,177,033
|
2,177,033
|
||||||||||||||||||
Total Comprehensive Loss
|
—
|
—
|
—
|
(53,254,817
|
)
|
2,177,033
|
(51,077,784
|
)
|
||||||||||||||||
Equity-settled share-based pay-ments
|
—
|
—
|
6,832,210
|
—
|
—
|
6,832,210
|
||||||||||||||||||
Share options exercised
|
16,905
|
(15,229
|
)
|
—
|
—
|
—
|
1,676
|
|||||||||||||||||
Balance as of December 31, 2019
|
3,132,631
|
211,006,606
|
25,142,213
|
(134,362,006
|
)
|
2,227,228
|
107,146,673
|
|||||||||||||||||
Loss for the Period
|
—
|
—
|
—
|
(33,983,614
|
)
|
—
|
(33,983,614
|
)
|
||||||||||||||||
Exchange differences on
translation of foreign currency
|
—
|
—
|
—
|
—
|
(5,954,019
|
)
|
(5,954,019
|
)
|
||||||||||||||||
Total Comprehensive Loss
|
—
|
—
|
—
|
(33,983,614
|
)
|
(5,954,019
|
)
|
(39,937,633
|
)
|
|||||||||||||||
Issuance of common shares
|
234,982
|
9,535,961
|
—
|
—
|
—
|
9,770,943
|
||||||||||||||||||
Transaction costs
|
—
|
(729,840
|
)
|
—
|
—
|
—
|
(729,840
|
)
|
||||||||||||||||
Equity-settled share-based pay-ments
|
—
|
—
|
1,116,791
|
—
|
—
|
1,116,791
|
||||||||||||||||||
Share options exercised
|
19,797
|
477,149
|
—
|
—
|
—
|
496,946
|
||||||||||||||||||
Balance as of December 31, 2020
|
3,387,410
|
220,289,876
|
26,259,004
|
(168,345,620
|
)
|
(3,726,791
|
)
|
77,863,880
|
||||||||||||||||
Loss for the Period
|
—
|
—
|
—
|
(45,630,059
|
)
|
—
|
(45,630,059
|
)
|
||||||||||||||||
Exchange differences on
translation of foreign currency
|
—
|
—
|
—
|
—
|
6,777,061
|
6,777,061
|
||||||||||||||||||
Total Comprehensive Loss
|
—
|
—
|
—
|
(45,630,059
|
)
|
6,777,061
|
(38,852,998
|
)
|
||||||||||||||||
Issuance of common shares
|
1,873,203
|
63,269,346
|
—
|
—
|
—
|
65,142,549
|
||||||||||||||||||
Transaction costs
|
—
|
(4,219,222
|
)
|
—
|
—
|
—
|
(4,219,222
|
)
|
||||||||||||||||
Equity-settled share-based pay-ments
|
—
|
—
|
4,332,205
|
—
|
—
|
4,332,205
|
||||||||||||||||||
Share options exercised
|
43,839
|
970,744
|
—
|
—
|
—
|
1,014,583
|
||||||||||||||||||
Balance as of December 31, 2021
|
5,304,452
|
280,310,744
|
30,591,209
|
(213,975,679
|
)
|
3,050,270
|
105,280,996
|
![]() |
|
in €
|
2021
|
2020
|
2019
|
|||||||||
Operating activities
|
||||||||||||
Loss for the Period
|
(45,630,059
|
)
|
(33,983,614
|
)
|
(53,254,817
|
)
|
||||||
Adjustments for:
|
||||||||||||
Depreciation & amortization of property and equipment, right-of-use assets and intangible assets
|
669,434
|
712,713
|
663,166
|
|||||||||
Net finance income
|
(2,004,757
|
)
|
40,810
|
(3,513,355
|
)
|
|||||||
Share-based payment expense
|
4,332,205
|
1,116,791
|
6,832,210
|
|||||||||
Net foreign exchange differences
|
111,606
|
(247,322
|
)
|
(368,477
|
)
|
|||||||
Other non-cash adjustments
|
—
|
3,436
|
60,628
|
|||||||||
Changes in:
|
||||||||||||
Other assets
|
(7,094,467
|
)
|
(1,554,611
|
)
|
(2,364,399
|
)
|
||||||
Employee benefits
|
(3,290
|
)
|
355,545
|
235,500
|
||||||||
Other liabilities
|
19,863
|
8,960
|
(209,948
|
)
|
||||||||
Liabilities from government grants received
|
8,300,000
|
—
|
—
|
|||||||||
Trade and other payables
|
316,112
|
(4,155,529
|
)
|
5,734,795
|
||||||||
Interest received
|
1,070,235
|
1,201,547
|
3,001,109
|
|||||||||
Interest paid
|
(23,633
|
)
|
(26,387
|
)
|
(20,903
|
)
|
||||||
Net cash used in operating activities
|
(39,936,750
|
)
|
(36,527,661
|
)
|
(43,204,492
|
)
|
||||||
Investing activities
|
||||||||||||
Purchase of intangible assets and property and equipment
|
(37,778
|
)
|
(94,189
|
)
|
(594,889
|
)
|
||||||
Purchase of non-current other financial assets
|
—
|
—
|
(75,543
|
)
|
||||||||
Purchase of current and non current financial assets
|
(97,516,417
|
)
|
(101,600,176
|
)
|
(82,547,409
|
)
|
||||||
Proceeds from the maturity of current financial assets
|
71,603,310
|
123,056,347
|
103,559,395
|
|||||||||
Net cash from/ (used in) investing activities
|
(25,950,885
|
)
|
21,361,982
|
20,341,554
|
||||||||
Financing activities
|
||||||||||||
Proceeds from issuance of common shares
|
65,142,549
|
9,770,944
|
—
|
|||||||||
Transaction costs from issuance of common shares
|
(4,219,222
|
)
|
(729,841
|
)
|
—
|
|||||||
Proceeds from exercise of share options
|
1,014,583
|
496,946
|
1,676
|
|||||||||
Repayment of lease liabilities
|
(360,644
|
)
|
(366,156
|
)
|
(296,020
|
)
|
||||||
Net cash from/ (used in) financing activities
|
61,577,266
|
9,171,893
|
(294,344
|
)
|
||||||||
Net increase/(decrease) in cash and cash equivalents
|
(4,310,369
|
)
|
(5,993,786
|
)
|
(23,157,282
|
)
|
||||||
Effect of exchange rate changes on cash and cash equivalents
|
4,591,683
|
(1,168,813
|
)
|
902,321
|
||||||||
Cash and cash equivalents at beginning of period
|
25,968,681
|
33,131,280
|
55,386,240
|
|||||||||
Cash and cash equivalents at end of period
|
26,249,995
|
25,968,681
|
33,131,280
|
![]() |
|
![]() |
|