Condensed Statements of Stockholders' Equity (Deficit) (unaudited) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive (Loss)	Accumulated Deficit
Beginning balances at Dec. 31, 2020	$ 53,839	$ 3	$ 221,904	$ 3	$ (168,071)
Beginning balances, shares at Dec. 31, 2020		25,553,172
Issuance of common stock in follow-on offering, net of underwriter discounts, commissions and issuance costs	107,582	$ 1	107,581
Issuance of common stock in follow-on offering, net of underwriter discounts, commissions and issuance costs, shares		6,764,704
Issuance of common stock under equity incentive plans including exercise of stock options	561		561
Issuance of common stock under equity incentive plans including exercise of stock options, shares		113,538
Vesting of early exercisable stock options	6		6
Vesting of early exercisable stock options, shares		7,319
Stock-based compensation	2,136		2,136		0
Net loss	(61,724)				(61,724)
Unrealized (loss) gain on marketable securities	(20)			(20)
Ending balance at Mar. 31, 2021	102,380	$ 4	332,188	(17)	(229,795)
Ending balance, shares at Mar. 31, 2021		32,438,733
Beginning balances at Dec. 31, 2020	53,839	$ 3	221,904	3	(168,071)
Beginning balances, shares at Dec. 31, 2020		25,553,172
Net loss	(78,487)
Unrealized (loss) gain on marketable securities	(4)
Ending balance at Jun. 30, 2021	90,928	$ 4	337,484	(1)	(246,559)
Ending balance, shares at Jun. 30, 2021		32,639,276
Beginning balances at Mar. 31, 2021	102,380	$ 4	332,188	(17)	(229,795)
Beginning balances, shares at Mar. 31, 2021		32,438,733
Issuance of common stock pursuant to ATM facility, net of offering costs	2,767	$ 0	2,767	0	0
Issuance of common stock pursuant to ATM facility, net of offering costs, shares		138,153
Issuance of common stock under equity incentive plans including exercise of stock options	186		186
Issuance of common stock under equity incentive plans including exercise of stock options, shares		56,934
Vesting of early exercisable stock options	5		5
Vesting of early exercisable stock options, shares		5,456
Stock-based compensation	2,338		2,338		0
Net loss	(16,764)				(16,764)
Unrealized (loss) gain on marketable securities	16	$ 0	0	16
Ending balance at Jun. 30, 2021	90,928	$ 4	337,484	(1)	(246,559)
Ending balance, shares at Jun. 30, 2021		32,639,276
Beginning balances at Dec. 31, 2021	58,070	$ 4	342,905	(47)	(284,792)
Beginning balances, shares at Dec. 31, 2021		32,765,788
Issuance of common stock under equity incentive plans including exercise of stock options	830		830
Issuance of common stock under equity incentive plans including exercise of stock options, shares		309,905
Vesting of early exercisable stock options	3		3
Vesting of early exercisable stock options, shares		1,728
Stock-based compensation	2,843		2,843
Net loss	(20,321)				(20,321)
Unrealized (loss) gain on marketable securities	(41)			(41)
Ending balance at Mar. 31, 2022	41,384	$ 4	346,581	(88)	(305,113)
Ending balance, shares at Mar. 31, 2022		33,077,421
Beginning balances at Dec. 31, 2021	58,070	$ 4	342,905	(47)	(284,792)
Beginning balances, shares at Dec. 31, 2021		32,765,788
Net loss	(37,672)
Unrealized (loss) gain on marketable securities	(9)
Ending balance at Jun. 30, 2022	26,642	$ 4	349,158	(56)	(322,464)
Ending balance, shares at Jun. 30, 2022		33,105,312
Beginning balances at Mar. 31, 2022	41,384	$ 4	346,581	(88)	(305,113)
Beginning balances, shares at Mar. 31, 2022		33,077,421
Issuance of common stock under equity incentive plans including exercise of stock options	53		53
Issuance of common stock under equity incentive plans including exercise of stock options, shares		26,163
Vesting of early exercisable stock options	3		3
Vesting of early exercisable stock options, shares		1,728
Stock-based compensation	2,521		2,521
Net loss	(17,351)				(17,351)
Unrealized (loss) gain on marketable securities	32			32
Ending balance at Jun. 30, 2022	$ 26,642	$ 4	$ 349,158	$ (56)	$ (322,464)
Ending balance, shares at Jun. 30, 2022		33,105,312