Exhibit 23.1

To the Board of Directors and Stockholders of Simplicity Esports and Gaming Company INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM’S CONSENT We consent to the incorporation by reference in this Registration Statement on Form S-8 of Simplicity Esports and Gaming Company (the “Company”) of our report dated August 31, 2020, relating to the financial statements and schedules which appear in the Company’s Annual Report on Form 10-K for the fiscal year ended May 31, 2020. We also consent to the reference to our Firm under the heading “Experts” in such Registration Statement on Form S-8. /s/ Prager Metis CPAs, LLC Prager Metis CPAs, LLC Basking Ridge, New Jersey March 18, 2021