X0101 EFFECT 33 LIVE 2017-10-05 17:30:00

N-1A

0001707770 T. Rowe Price Multi-Strategy Total Return Fund, Inc. 333-218649 S000058608 T. Rowe Price Multi-Strategy Total Return Fund C000192517 T. Rowe Price Multi-Strategy Total Return Fund S000058608 T. Rowe Price Multi-Strategy Total Return Fund C000192518 T. Rowe Price Multi-Strategy Total Return Fund-Advisor Class S000058608 T. Rowe Price Multi-Strategy Total Return Fund C000192519 T. Rowe Price Multi-Strategy Total Return Fund-I Class