X0306 4 2022-02-10 0 0001707502 Solid Biosciences Inc. SLDB 0001727460 Ganot Ilan C/O SOLID BIOSCIENCES INC. 141 PORTLAND STREET, 5TH FLOOR CAMBRIDGE MA 02139 1 1 0 0 CEO & President Common Stock 2022-02-10 4 S 0 463 1.1202 D 2518 I Wife Common Stock 1202093 D Common Stock 290914 I See Footnote This sale was made to cover withholding taxes following the vesting of the previously granted restricted stock units. The shares were sold pursuant to a written instruction under Rule 10b5-1(c)(1). Represents 1,141,462 shares held by Mr. Ganot as an individual, and 60,631 shares held by Mr. Ganot and Annie Ganot as joint tenants with right of survivorship. Includes 2,272 shares acquired by Mr. Ganot under the Solid Biosciences Employee Stock Purchase Plan on September 1, 2021. Represents 290,914 shares held by Adam Ganot and Annie Ganot, and their successors, as the trustees for the Ilan Ganot 2017 Irrevocable Trust dated March 3, 2017. /s/ Erin P. Brennan as attorney-in-fact for Ilan Ganot 2022-03-08