X0306 4 2021-01-27 0 0001707502 Solid Biosciences Inc. SLDB 0001727460 Ganot Ilan C/O SOLID BIOSCIENCES INC. 141 PORTLAND STREET, 5TH FLOOR CAMBRIDGE MA 02139 1 1 0 0 CEO & President Common Stock 2021-01-27 4 M 0 35500 A 1210534 D Common Stock 2021-01-28 4 S 0 10713 6.1398 D 1199821 D Common Stock 290914 I See Footnote Common Stock 3483 I Wife Restricted Stock Units 2021-01-27 4 M 0 35500 0.00 D Common Stock 35500 0 D Restricted Stock units convert into common stock on a one-for-one basis. Represents 1,149,903 shares held by Mr. Ganot as an individual, and 60,631 shares held by Mr. Ganot and Annie Ganot as joint tenants with right of survivorship. This sale was made to cover withholding taxes following the vesting of the previously granted restricted stock units. Represents 1,139,190 shares held by Mr. Ganot as an individual, and 60,631 shares held by Mr. Ganot and Annie Ganot as joint tenants with right of survivorship. Represents 290,914 shares held by Adam Ganot and Annie Ganot, and their successors, as the trustees for the Ilan Ganot 2017 Irrevocable Trust dated March 3, 2017. On January 27, 2020, the reporting person was granted 71,000 restricted stock units, vesting in two equal installments. Fifty percent vested six months after the grant date with the remaining fifty percent vesting on the first anniversary of the grant date. /s/ Ilan Ganot 2021-01-29