<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001529297</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001707502</issuerCik>
<issuerName>Solid Biosciences Inc.</issuerName>
<secFileNumber>001-38360</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">500 Rutherford Avenue</street1>
<city xmlns="http://www.sec.gov/edgar/common">Charlestown</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">02129</zipCode>
</issuerAddress>
<issuerContactPhone>(617)-337-4680</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Howton David T</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>ETRADE FINANCIAL CORPORATION</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
<city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>5072</noOfUnitsSold>
<aggregateMarketValue>28396.05</aggregateMarketValue>
<noOfUnitsOutstanding>39954607</noOfUnitsOutstanding>
<approxSaleDate>12/03/2024</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>12/02/2024</acquiredDate>
<natureOfAcquisitionTransaction>Settlement of vested restricted stock units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>5072</amountOfSecuritiesAcquired>
<paymentDate>12/02/2024</paymentDate>
<natureOfPayment>Compensation</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The sales reported on this Form 144 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units. These sales do not represent discretionary trades by the Reporting Person.</remarks>
<noticeSignature>
<noticeDate>12/04/2024</noticeDate>
<signature>/s/ David Tyronne Howton </signature>
</noticeSignature>
</formData>
</edgarSubmission>
