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Pay vs Performance Disclosure - USD ($)
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Pay vs Performance Disclosure          
Pay vs Performance Disclosure, Table
PEO 1PEO 1PEO 2PEO 2Value of Initial Fixed $100
Investment Based On:
Fiscal YearSummary Compensation Table Total for PEO Scangos, George (former CEO)Compensation Actually Paid to PEO Scangos, George (former CEO)Summary Compensation Table Total for PEO De Backer, MarianneCompensation Actually Paid to PEO De Backer, MarianneAverage Summary Compensation Table Total for non-PEO NEOsAverage Compensation Actually Paid to non-PEO NEOsVIR Total Shareholder ReturnPeer Group Total Shareholder ReturnNet Income
($ in thousands)
2025$—$—$7,834,045$3,104,984$2,004,699$1,293,024$22.52$124.75$(437,987)
2024$—$—$9,255,903$3,992,869$1,896,056$1,083,873$27.41$93.49$(521,960)
2023$338,200$(4,717,018)$39,491,495$18,206,997$3,530,255$203,774$37.57$94.03$(615,117)
2022$7,479,898$3,498,740$—$—$4,044,309$1,084,615$94.51$89.90$515,837
2021$20,682,838$15,032,868$—$—$5,685,910$6,198,242$156.35$100.02$528,584
       
Named Executive Officers, Footnote Dr. Scangos is our PEO 1 (2021-2023) and Dr. De Backer is our PEO 2 (2023-2025). Our Other NEOs were Jeffrey Calcagno, M.D. (2023), Vanina de Verneuil, J.D. (2024 and 2025), Mark Eisner, M.D., M.P.H (2024 and 2025), Johanna Friedl-Naderer (2022 and 2023), Ann (Aine) Hanly (2021-2024), Howard Horn (2021-2023), Sung Lee (2023 and 2024), Jason O’Byrne, MBA (2024 and 2025), Phillip Pang, M.D., PhD. (2021-2023), Steven Rice (2023), and Herbert (Skip) Virgin, M.D., Ph.D. (2021 and 2022).        
PEO Total Compensation Amount $ 7,834,045        
PEO Actually Paid Compensation Amount $ 3,104,984        
Adjustment To PEO Compensation, Footnote The following table describes the adjustments, each of which is prescribed by SEC rule, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our executives during 2025, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act.
Adjustments
Prior FYE
Current FYE
Fiscal Year
PEO 2
12/31/2024
12/31/2025
2025
Other NEOs*
12/31/2024
12/31/2025
2025
SCT Total$7,834,045 $2,004,699 
 – Grant Date Fair Value of Option Awards and Stock Awards Granted in Fiscal Year(5,804,160)(927,053)
 + Fair Value at Fiscal Year-End of Outstanding and Unvested Option Awards and Stock Awards Granted in Fiscal Year
3,196,830 510,605 
 + Change in Fair Value of Outstanding and Unvested Option Awards and Stock Awards Granted in Prior Fiscal Years
(1,687,805)(214,476)
 + Fair Value at Vesting of Option Awards and Stock Awards Granted in Fiscal Year That Vested During Fiscal Year
— — 
 + Change in Fair Value as of Vesting Date of Option Awards and Stock Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year(433,926)(80,751)
 – Fair Value as of Prior Fiscal Year-End of Option Awards and Stock Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year
— — 
 + Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation
— — 
Compensation Actually Paid$3,104,984 $1,293,024 
*Amounts presented are averages for the entire group of Other NEOs. Valuation assumptions used to calculate fair values did not materially differ from those used to calculate fair values at the time of grant as reflected in the SCT Amounts.
       
Non-PEO NEO Average Total Compensation Amount $ 2,004,699 $ 1,896,056 $ 3,530,255 $ 4,044,309 $ 5,685,910
Non-PEO NEO Average Compensation Actually Paid Amount $ 1,293,024 1,083,873 203,774 1,084,615 6,198,242
Adjustment to Non-PEO NEO Compensation Footnote The following table describes the adjustments, each of which is prescribed by SEC rule, to calculate the CAP Amounts from the SCT Amounts. The SCT Amounts and the CAP Amounts do not reflect the actual amount of compensation earned by or paid to our executives during 2025, but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act.
Adjustments
Prior FYE
Current FYE
Fiscal Year
PEO 2
12/31/2024
12/31/2025
2025
Other NEOs*
12/31/2024
12/31/2025
2025
SCT Total$7,834,045 $2,004,699 
 – Grant Date Fair Value of Option Awards and Stock Awards Granted in Fiscal Year(5,804,160)(927,053)
 + Fair Value at Fiscal Year-End of Outstanding and Unvested Option Awards and Stock Awards Granted in Fiscal Year
3,196,830 510,605 
 + Change in Fair Value of Outstanding and Unvested Option Awards and Stock Awards Granted in Prior Fiscal Years
(1,687,805)(214,476)
 + Fair Value at Vesting of Option Awards and Stock Awards Granted in Fiscal Year That Vested During Fiscal Year
— — 
 + Change in Fair Value as of Vesting Date of Option Awards and Stock Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year(433,926)(80,751)
 – Fair Value as of Prior Fiscal Year-End of Option Awards and Stock Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year
— — 
 + Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation
— — 
Compensation Actually Paid$3,104,984 $1,293,024 
*Amounts presented are averages for the entire group of Other NEOs. Valuation assumptions used to calculate fair values did not materially differ from those used to calculate fair values at the time of grant as reflected in the SCT Amounts.
       
Compensation Actually Paid vs. Total Shareholder Return
The following charts show graphically the relationships over the past three years of the CAP Amounts for our PEOs and Other NEOs as compared to our cumulative total shareholder return (TSR), Peer Group TSR and net income, as well as the relationship between TSR and Peer Group TSR:
Compensation Actually Paid versus TSR and Peer Group TSR(1)
75655
(1) The peer group is Nasdaq Biotechnology Index.
       
Compensation Actually Paid vs. Net Income
Compensation Actually Paid versus Net Income
75749
       
Total Shareholder Return Vs Peer Group
The following charts show graphically the relationships over the past three years of the CAP Amounts for our PEOs and Other NEOs as compared to our cumulative total shareholder return (TSR), Peer Group TSR and net income, as well as the relationship between TSR and Peer Group TSR:
Compensation Actually Paid versus TSR and Peer Group TSR(1)
75655
(1) The peer group is Nasdaq Biotechnology Index.
       
Total Shareholder Return Amount $ 22.52 27.41 37.57 94.51 156.35
Peer Group Total Shareholder Return Amount 124.75 93.49 94.03 89.90 100.02
Net Income (Loss) (437,987,000) (521,960,000) (615,117,000) 515,837,000 528,584,000
Dr. De Backer [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount 7,834,045 9,255,903 39,491,495    
PEO Actually Paid Compensation Amount $ 3,104,984 $ 3,992,869 $ 18,206,997    
PEO Name Dr. De Backer Dr. De Backer Dr. De Backer    
Dr. Scangos [Member]          
Pay vs Performance Disclosure          
PEO Total Compensation Amount     $ 338,200 7,479,898 20,682,838
PEO Actually Paid Compensation Amount     $ (4,717,018) $ 3,498,740 $ 15,032,868
PEO Name     Dr. Scangos Dr. Scangos Dr. Scangos
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount $ (5,804,160)        
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 3,196,830        
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (1,687,805)        
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (433,926)        
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
PEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (927,053)        
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 510,605        
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (214,476)        
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount (80,751)        
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount 0        
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year          
Pay vs Performance Disclosure          
Adjustment to Compensation, Amount $ 0