Segment Reporting - Schedule of Segment Reporting Information, by Segment (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Segment revenue	$ 68,556	$ 74,205	$ 86,180
Less: Segment expenses
Cost of revenue	26	845	2,765
Research and development
Selling, general and administrative	92,074	119,031	174,441
Restructuring, long-lived assets impairment and related charges, net	(182)	34,995	13,559
Net loss	(437,987)	(521,960)	(615,117)
Reportable Segment
Segment Reporting Information [Line Items]
Segment revenue	68,556	74,205	86,180
Less: Segment expenses
Cost of revenue	26	845	2,765
Research and development
Personnel	125,274	162,960	189,418
Licenses, collaborations and contingent consideration	125,058	129,846	30,215
Clinical costs	87,173	57,624	121,422
Contract manufacturing	47,622	40,081	114,262
Other R&D	70,839	115,988	124,403
Selling, general and administrative	92,074	119,031	174,441
Restructuring, long-lived assets impairment and related charges, net	(182)	34,995	13,559
Plus: Other segment items	41,341	65,205	69,188
Net loss	$ (437,987)	$ (521,960)	$ (615,117)