Collaboration and License Agreements - Schedule of Collaboration Revenue (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total license and collaboration revenue under GSK 2020 Agreement	$ 68,556	$ 74,205	$ 86,180
Profit-sharing amount
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total license and collaboration revenue under GSK 2020 Agreement	(1,138)	9,078	1,536
Profit-sharing amount constrained
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total license and collaboration revenue under GSK 2020 Agreement	0	(699)	0
Profit-sharing amount previously constrained, released
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total license and collaboration revenue under GSK 2020 Agreement	0	0	35,730
Total license and collaboration revenue under GSK 2020 Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Total license and collaboration revenue under GSK 2020 Agreement	$ (1,138)	$ 8,379	$ 37,266