Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (395,064)	$ (417,371)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	8,782	11,673
Amortization of premiums on investments, net	7,925	3,229
Noncash lease expense	3,655	4,149
Change in fair value of equity investments	(4,335)	4,356
Change in estimated fair value of contingent consideration	11,570	7,209
Payment of contingent consideration in excess of acquisition date fair value	(17,140)	0
Stock-based compensation	37,866	62,616
In-process research and development impairment	0	3,512
Long-lived assets impairment and disposal loss	399	28,557
Other non-cash items, net	40	(326)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	10,152	9,021
Other assets	(3,924)	854
Accounts payable	2,042	948
Accrued liabilities and other long-term liabilities	(19,613)	(15,530)
Operating lease liabilities	(5,045)	(10,432)
Deferred revenue	(3,215)	(51,182)
Net cash used in operating activities	(365,905)	(358,717)
CASH FLOWS FROM INVESTING ACTIVITIES:
Proceeds from sale of equipment	363	917
Purchases of long-lived assets	(4,484)	(5,306)
Purchases of investments	(630,512)	(1,074,480)
Maturities and sales of investments	858,353	1,437,499
Net cash provided by investing activities	223,720	358,630
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from exercise of stock options	1,348	701
Issuance of common stock under ESPP	1,757	2,602
Other financing activities	(359)	(178)
Net cash provided by financing activities	2,746	3,125
Net (decrease) increase in cash, cash equivalents and restricted cash and cash equivalents	(139,439)	3,038
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period	318,695	261,292
Cash, cash equivalents and restricted cash and cash equivalents at end of period	179,256	264,330
NONCASH INVESTING AND FINANCING ACTIVITIES:
Obtaining a right-of-use asset in exchange for a lease liability	7,329	0
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
Net cash paid for income tax	2,266	0
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH AND CASH EQUIVALENTS TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:
Cash and cash equivalents	170,084	168,350
Restricted cash and cash equivalents, current	2,215	89,598
Restricted cash and cash equivalents, noncurrent	6,957	6,382
Total cash, cash equivalents and restricted cash and cash equivalents	$ 179,256	$ 264,330