Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (65,276)	$ (140,956)
Adjustments to reconcile net loss to net cash used in operating activities:
Change in estimated constraint on profit-sharing amount	685	(31,541)
Depreciation and amortization	4,517	5,638
Amortization of premiums (accretion of discounts) on investments, net	238	(9,365)
Noncash lease expense	1,447	2,173
Change in fair value of equity investments	5,915	13,103
Change in estimated fair value of contingent consideration	1,650	(1,246)
Stock-based compensation	23,757	25,481
Other non-cash items, net	(176)	206
Changes in operating assets and liabilities:
Receivable from collaboration	(401)	2,093
Prepaid expenses and other current assets	1,834	9,493
Other assets	(86)	(1,984)
Accounts payable	735	6,564
Accrued liabilities and other long-term liabilities	(30,003)	(4,036)
Operating lease liabilities	(4,067)	(3,105)
Deferred revenue	(50,159)	1,700
Net cash used in operating activities	(109,390)	(125,782)
CASH FLOWS FROM INVESTING ACTIVITIES:
Proceeds from sale of equipment	533	0
Purchases of property and equipment	(1,872)	(6,867)
Purchases of investments	(562,939)	(384,513)
Maturities and sales of investments	592,698	489,459
Net cash provided by investing activities	28,420	98,079
CASH FLOWS FROM FINANCING ACTIVITIES:
Payment of principal on financing lease obligation	(69)	(66)
Proceeds from exercise of stock options	221	2,310
Contributions from noncontrolling interest owners	0	100
Net cash provided by financing activities	152	2,344
Net decrease in cash, cash equivalents and restricted cash and cash equivalents	(80,818)	(25,359)
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period	261,292	867,968
Cash, cash equivalents and restricted cash and cash equivalents at end of period	180,474	842,609
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH AND CASH EQUIVALENTS TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:
Cash and cash equivalents	160,711	824,913
Restricted cash and cash equivalents, current	13,335	10,957
Restricted cash and cash equivalents, noncurrent	6,428	6,739
Total cash, cash equivalents and restricted cash and cash equivalents	$ 180,474	$ 842,609