Consolidated Statements of Stockholders’ Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	(Accumulated Deficit) Retained Earnings	Noncontrolling interest
Beginning balance (in shares) at Dec. 31, 2020		127,416,740
Beginning balance at Dec. 31, 2020	$ 716,852	$ 13	$ 1,385,301	$ (1,278)	$ (667,184)	$ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock in connection with a collaboration agreement (in shares)		1,924,927
Issuance of common stock in connection with a collaboration agreement	85,213		85,213
Issuance of common stock to settle a contingent consideration (in shares)		42,737
Issuance of common stock to settle a contingent consideration	1,860		1,860
Vesting of restricted common stock (in shares)		89,261
Exercise of stock option (in shares)		1,622,718
Exercise of stock options	13,077		13,077
Issuance of common stock under employee stock purchase plan (in shares)		65,021
Issuance of common stock under employee stock purchase plan	2,300		2,300
Stock-based compensation	83,784		83,784
Other comprehensive income (loss)	179			179
Net (loss) income	528,584				528,584
Ending balance (in shares) at Dec. 31, 2021		131,161,404
Ending balance at Dec. 31, 2021	1,431,849	$ 13	1,571,535	(1,099)	(138,600)	0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock in connection with grant agreement (in shares)		881,365
Issuance of common stock in connection with a grant agreement	28,462		28,462
Vesting of restricted common stock (in shares)		349,496
Exercise of stock option (in shares)		696,963
Exercise of stock options	4,534		4,534
Issuance of common stock under employee stock purchase plan (in shares)		147,459
Issuance of common stock under employee stock purchase plan	3,222		3,222
Stock-based compensation	102,082		102,082
Other comprehensive income (loss)	(8,023)			(8,023)
Net (loss) income	$ 515,837				515,837
Ending balance (in shares) at Dec. 31, 2022	133,236,687	133,236,687
Ending balance at Dec. 31, 2022	$ 2,077,963	$ 13	1,709,835	(9,122)	377,237	0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Vesting of restricted common stock (in shares)		734,662
Exercise of stock option (in shares)		487,014
Exercise of stock options	3,484		3,484
Issuance of common stock under employee stock purchase plan (in shares)		322,923
Issuance of common stock under employee stock purchase plan	4,283		4,283
Stock-based compensation	111,316		111,316
Other comprehensive income (loss)	8,307			8,307
Contributions from noncontrolling interest owners	100					100
Increase in ownership interest in a subsidiary	(100)		(56)			(44)
Net (loss) income	$ (615,117)				(615,061)	(56)
Ending balance (in shares) at Dec. 31, 2023	134,781,286	134,781,286
Ending balance at Dec. 31, 2023	$ 1,590,236	$ 13	$ 1,828,862	$ (815)	$ (237,824)	$ 0