Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
CASH FLOWS FROM OPERATING ACTIVITIES:
Net (loss) income	$ (499,144)	$ 617,440
Adjustments to reconcile net (loss) income to net cash (used in) provided by operating activities:
Change in estimated constraint on profit-sharing amount	(28,101)	353,526
Depreciation and amortization	14,573	4,431
Amortization of intangible assets	399	399
Accretion of discounts on investments, net	(10,057)	(1,315)
Payment of contingent consideration in excess of acquisition date fair value	0	(93,803)
Noncash lease expense	6,218	6,473
Change in fair value of equity investments	20,895	120,019
Change in estimated fair value of contingent consideration	(637)	7,890
Stock-based compensation	83,044	77,217
In-process research and development impairment	6,899	0
Long-lived assets impairment	7,474	0
Other	(578)	301
Changes in operating assets and liabilities:
Receivable from collaboration	3,041	491,872
Prepaid expenses and other current assets	54,194	11,023
Other assets	(150)	(3,434)
Accounts payable	(1,895)	(2,003)
Accrued liabilities and other long-term liabilities	(316,918)	65,144
Operating lease liabilities	(9,910)	(2,547)
Deferred revenue	(205)	(24,506)
Net cash (used in) provided by operating activities	(670,858)	1,628,127
CASH FLOWS FROM INVESTING ACTIVITIES:
Proceeds from sale of an equipment	0	22
Purchases of property and equipment	(20,038)	(55,432)
Purchases of investments	(1,197,199)	(1,069,752)
Maturities of investments	1,486,677	84,836
Net cash provided by (used in) investing activities	269,440	(1,040,326)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock in connection with a grant agreement	0	28,462
Payment of principal on financing lease obligation	(200)	(183)
Proceeds from exercise of stock options	3,395	3,602
Issuance of common stock under ESPP	2,605	2,066
Contributions from noncontrolling interest owners	100	0
Increase in ownership interest in a subsidiary	(100)	0
Payment of contingent consideration	0	(1,197)
Net cash provided by financing activities	5,800	32,750
Net (decrease) increase in cash, cash equivalents and restricted cash and cash equivalents	(395,618)	620,551
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period	867,968	363,415
Cash, cash equivalents and restricted cash and cash equivalents at end of period	472,350	983,966
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH AND CASH EQUIVALENTS TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:
Cash and cash equivalents	452,100	963,735
Restricted cash and cash equivalents, current	13,193	12,955
Restricted cash and cash equivalents, noncurrent	7,057	7,276
Total cash, cash equivalents and restricted cash and cash equivalents	$ 472,350	$ 983,966