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Collaboration and License Agreements (Tables)
9 Months Ended
Sep. 30, 2023
Collaboration and License Agreements  
Schedule of Collaboration Revenue
During the three and nine months ended September 30, 2023 and 2022, the Company recorded profit-sharing amounts, profit-sharing amounts constrained, and profit-sharing amounts constrained, released as components of collaboration revenue in the unaudited condensed consolidated statements of operations, as follows:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2023202220232022
(in thousands)
Collaboration revenue, net
Profit-sharing amount$(6,038)$291,226 $(7,198)$1,863,374 
Profit-sharing amount constrained— (2,431)— (399,864)
Profit-sharing amount previously constrained, released1,651 20,350 35,606 20,350 
Total collaboration revenue, net$(4,387)$309,145 $28,408 $1,483,860