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Balance Sheet Components
 9 Months Ended
Sep. 30, 2023
Balance Sheet Related Disclosures [Abstract]  
Balance Sheet Components Balance Sheet Components
Property and Equipment, net
Property and equipment, net consists of the following:
September 30,
2023		December 31,
2022
(in thousands)
Laboratory equipment$43,158 $36,533 
Computer equipment2,684 2,545 
Furniture and fixtures2,887 2,852 
Leasehold improvements80,207 84,422 
Construction in progress22 — 
Property and equipment, gross128,958 126,352 
Less accumulated depreciation(29,649)(20,743)
Total property and equipment, net$99,309 $105,609 
Depreciation expenses were $4.5 million and $14.6 million for the three and nine months ended September 30, 2023, respectively, and $1.6 million and $4.4 million for the three and nine months ended September 30, 2022, respectively.
Accrued and Other Liabilities
Accrued and other liabilities consist of the following:
September 30,
2023		December 31,
2022
(in thousands)
Research and development expenses$65,693 $48,880 
Payroll and related expenses27,176 28,286 
Accrued income taxes15,415 15,228 
Operating lease liabilities, current13,557 4,137 
Excess funds payable under grant agreements9,217 7,652 
Net profit-sharing amount6,964 357,762 
Other professional and consulting expenses4,336 3,987 
Other accrued expenses3,711 12,711 
Accrued royalties42 10,447 
Total accrued and other liabilities$146,111 $489,090