Balance Sheet Components

6 Months Ended

Jun. 30, 2023

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

Balance Sheet Components

Property and Equipment, net

Property and equipment, net consists of the following:

	June 30, 2023		December 31, 2022
	(in thousands)
Laboratory equipment	$	44,221	$	36,533
Computer equipment	2,653		2,545
Furniture and fixtures	2,935		2,852
Leasehold improvements	80,210		84,422
Construction in progress	6		—
Property and equipment, gross	130,025		126,352
Less accumulated depreciation	(25,899)		(20,743)
Total property and equipment, net	$	104,126	$	105,609

Depreciation expenses were $4.6 million and $10.1 million for the three and six months ended June 30, 2023, respectively, and $1.5 million and $2.9 million for the three and six months ended June 30, 2022, respectively.

Accrued and Other Liabilities

Accrued and other liabilities consist of the following:

	June 30, 2023		December 31, 2022
	(in thousands)
Net profit-sharing amount	$	78,073	$	357,762
Research and development expenses	53,297		48,880
Payroll and related expenses	19,698		28,286
Accrued income taxes	15,498		15,228
Operating lease liabilities, current	13,536		4,137
Excess funds payable under grant agreements	7,611		7,652
Other professional and consulting expenses	5,108		3,987
Other accrued expenses	4,355		12,711
Accrued royalties	404		10,447
Total accrued and other liabilities	$	197,580	$	489,090