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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $ (193,016) $ (110,912)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,185 2,435
Amortization of intangible assets 918 918
Impairment of intangible assets 832  
Amortization of premiums (accretion of discounts) on investments, net 1,052 (571)
Noncash lease expense 2,498  
Change in estimated fair value of contingent consideration 44,432 819
Payment of contingent consideration in excess of acquisition date fair value (6,453)  
Change in estimated fair value of derivative liability 16,796  
Change in estimated fair value of convertible preferred stock warrant liability   3,401
Common stock issued in connection with license agreement   617
Stock-based compensation 17,299 6,040
Other 17  
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (416) (109)
Other assets (2,168) (1,399)
Accounts payable 1,041 428
Accrued liabilities and other long-term liabilities 13,183 5,678
Operating lease liabilities (2,343)  
Deferred revenue (5,746) 1,908
Net cash used in operating activities (108,889) (90,747)
CASH FLOWS FROM INVESTING ACTIVITIES:    
Purchases of property and equipment (4,119) (7,388)
Purchases of investments (363,399) (495,934)
Maturities of investments 296,763 320,933
Proceeds from disposal of an asset held for sale 180  
Net cash used in investing activities (70,575) (182,389)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock 323,214  
Proceeds from issuance of convertible preferred stock, net of issuance costs   317,335
Payment of contingent consideration (3,547)  
Proceeds received from financing lease obligation   1,202
Payment of principal on financing lease obligation (173) (38)
Payment of offering costs related to initial public offering   (3,686)
Proceeds from repayment of promissory notes   3,265
Proceeds from exercise of stock options 3,540 1,066
Net cash provided by financing activities 529,733 319,144
Net increase in cash, cash equivalents and restricted cash and cash equivalents 350,269 46,008
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period 122,816 59,362
Cash, cash equivalents and restricted cash and cash equivalents at end of period 473,085 105,370
NONCASH INVESTING AND FINANCING ACTIVITIES:    
Property and equipment purchases included in accounts payable and accrued liabilities 598 200
Reclassification of derivative liability to additional paid-in capital 29,245  
Operating lease liabilities obtained in exchange of right-of-use asset 437  
Deferred offering costs in accounts payable and accrued liabilities   1,938
Advanced proceeds applied to convertible preferred stock issuance   10,140
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:    
Cash and cash equivalents 462,521 93,698
Restricted cash and cash equivalents, current 9,363 8,822
Restricted cash and cash equivalents, noncurrent 1,201 2,850
Cash, cash equivalents and restricted cash and cash equivalents at end of period 473,085 $ 105,370
Collaboration Agreement    
CASH FLOWS FROM FINANCING ACTIVITIES:    
Proceeds from issuance of common stock $ 206,699