Collaboration and License Agreements - Collaboration Collaboration revenue (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Collaboration revenue, net
Profit-sharing amount	$ 1,875,147	$ 917,194
Profit-sharing amount constrained	(369,678)	0
Total collaboration revenue, net	$ 1,505,469	$ 917,194