Balance Sheet Components

12 Months Ended

Dec. 31, 2022

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

8.Balance Sheet Components

Property and Equipment, net

Property and equipment, net consists of the following:

	December 31,
	2022			2021
	(in thousands)
Laboratory equipment	$	36,533		$	20,012
Computer equipment		2,545			1,112
Furniture and fixtures		2,852			1,443
Leasehold improvements		84,422			7,834
Construction in progress		—			26,925
Property and equipment, gross		126,352			57,326
Less accumulated depreciation and amortization		(20,743	)		(14,492	)
Total property and equipment, net	$	105,609		$	42,834

Depreciation and amortization expenses were $6.3 million, $5.3 million and $4.4 million for the years ended December 31, 2022, 2021 and 2020, respectively.

Accrued and Other Liabilities

Accrued and other liabilities consist of the following:

	December 31,
	2022		2021
	(in thousands)
Milestone payable	$	—	$	95,000
Net profit-sharing constrained		357,762	$	—
Accrued royalties		10,447		58,672
Research and development expenses		48,880		28,073
Payroll and related expenses		28,286		29,753
Accrued income taxes		15,228		6,217
Excess funds payable under grant agreements		7,652		1,825
Operating lease liabilities, current		4,137		3,927
Other professional and consulting expenses		3,987		2,791
Other accrued expenses		12,711		10,254
Total accrued and other liabilities	$	489,090	$	236,512