Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ 442,128	$ (107,098)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Change in estimated constraint on profit-sharing amount	397,433	0
Depreciation and amortization	2,882	2,538
Amortization of intangible assets	266	266
Amortization of premiums (accretion of discounts) on investments, net	1,732	(238)
Payment for contingent consideration in excess of acquisition date fair value	(93,803)	0
Noncash lease expense	4,283	2,973
Change in fair value of equity investments	106,428	0
Change in estimated fair value of contingent consideration	5,633	42,918
Stock-based compensation	52,403	36,469
Other	292	32
Changes in operating assets and liabilities:
Receivable from collaboration	433,689	0
Prepaid expenses and other current assets	(5,472)	521
Other assets	(41)	(857)
Accounts payable	2,444	4,933
Accrued liabilities and other long-term liabilities	145,381	(22,287)
Operating lease liabilities	(1,012)	(93)
Deferred revenue	15,559	90,452
Net cash provided by operating activities	1,510,225	50,529
CASH FLOWS FROM INVESTING ACTIVITIES:
Proceeds from sale of an equipment	11	0
Purchases of property and equipment	(36,439)	(2,744)
Purchases of investments	(341,293)	(55,729)
Maturities of investments	0	221,382
Net cash (used in) provided by investing activities	(377,721)	162,909
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock in connection with a grant agreement	28,462	0
Proceeds from issuance of common stock in connection with a collaboration agreement	0	85,213
Payment of principal on financing lease obligation	(124)	(126)
Proceeds from exercise of stock options	1,558	5,945
Issuance of common stock under ESPP	2,066
Payment of contingent consideration	(1,197)	0
Net cash provided by financing activities	30,765	91,032
Net increase in cash, cash equivalents and restricted cash and cash equivalents	1,163,269	304,470
Cash, cash equivalents and restricted cash and cash equivalents at beginning of period	363,415	451,487
Cash, cash equivalents and restricted cash and cash equivalents at end of period	1,526,684	755,957
NONCASH INVESTING AND FINANCING ACTIVITIES:
Property and equipment purchases included in accounts payable and accrued liabilities	8,755	2,485
Operating lease liabilities obtained in exchange of right-of-use asset	3,942	0
SUPPLEMENTAL DISCLOSURE OF CASHFLOW INFORMATION
Cash paid during the period for income tax	89,416	0
RECONCILIATION OF CASH, CASH EQUIVALENTS AND RESTRICTED CASH TO THE CONDENSED CONSOLIDATED BALANCE SHEETS:
Cash and cash equivalents	1,505,183	741,951
Restricted cash and cash equivalents, current	13,147	7,004
Restricted cash and cash equivalents, noncurrent	8,354	7,002
Total cash, cash equivalents and restricted cash	$ 1,526,684	$ 755,957