Condensed Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	Retained Earnings (Accumulated Deficit)
Beginning balance at Dec. 31, 2020	$ 716,852	$ 13	$ 1,385,301	$ (1,278)	$ (667,184)
Beginning balance (in shares) at Dec. 31, 2020		127,416,740
Ending balance at Mar. 31, 2021	650,951	$ 13	1,488,337	(1,304)	(836,095)
Ending balance (in shares) at Mar. 31, 2021		129,891,856
Beginning balance at Dec. 31, 2020	716,852	$ 13	1,385,301	(1,278)	(667,184)
Beginning balance (in shares) at Dec. 31, 2020		127,416,740
Issuance of common stock in connection with a collaboration agreement	85,213		85,213
Issuance of common stock in connection with a collaboration agreement (in shares)		1,924,927
Vesting of restricted common stock (in shares)		87,409
Exercise of stock options	5,945		5,945
Exercise of stock option (in shares)		1,050,899
Stock-based compensation	36,469		36,469
Other comprehensive income (loss)	(56)			(56)
Net (loss) income	(107,098)				(107,098)
Ending balance at Jun. 30, 2021	737,325	$ 13	1,512,928	(1,334)	(774,282)
Ending balance (in shares) at Jun. 30, 2021		130,479,975
Beginning balance at Mar. 31, 2021	650,951	$ 13	1,488,337	(1,304)	(836,095)
Beginning balance (in shares) at Mar. 31, 2021		129,891,856
Vesting of restricted common stock (in shares)		34,446
Exercise of stock options	3,593		3,593
Exercise of stock option (in shares)		553,673
Stock-based compensation	20,998		20,998
Other comprehensive income (loss)	(30)			(30)
Net (loss) income	61,813				61,813
Ending balance at Jun. 30, 2021	737,325	$ 13	1,512,928	(1,334)	(774,282)
Ending balance (in shares) at Jun. 30, 2021		130,479,975
Beginning balance at Dec. 31, 2021	$ 1,431,849	$ 13	1,571,535	(1,099)	(138,600)
Beginning balance (in shares) at Dec. 31, 2021	131,161,404	131,161,404
Issuance of common stock under employee stock purchase plan (Shares)		94,175
Issuance of common stock under employee stock purchase plan	$ 2,066		2,066
Issuance of common stock in connection with a collaboration agreement	28,462		28,462
Issuance of common stock in connection with a collaboration agreement (in shares)		881,365
Vesting of restricted common stock (in shares)		270,598
Exercise of stock options	1,558		1,558
Exercise of stock option (in shares)		190,270
Stock-based compensation	52,403		52,403
Other comprehensive income (loss)	(6,454)			(6,454)
Net (loss) income	442,128				442,128
Ending balance at Jun. 30, 2022	$ 1,952,012	$ 13	1,656,024	(7,553)	303,528
Ending balance (in shares) at Jun. 30, 2022	132,597,812	132,597,812
Beginning balance at Mar. 31, 2022	$ 2,001,014	$ 13	1,625,785	(4,805)	380,021
Beginning balance (in shares) at Mar. 31, 2022		132,353,441
Issuance of common stock under employee stock purchase plan (Shares)		94,175
Issuance of common stock under employee stock purchase plan	2,066		2,066
Vesting of restricted common stock (in shares)		53,712
Exercise of stock options	1,074		1,074
Exercise of stock option (in shares)		96,484
Stock-based compensation	27,099		27,099
Other comprehensive income (loss)	(2,748)			(2,748)
Net (loss) income	(76,493)				(76,493)
Ending balance at Jun. 30, 2022	$ 1,952,012	$ 13	$ 1,656,024	$ (7,553)	$ 303,528
Ending balance (in shares) at Jun. 30, 2022	132,597,812	132,597,812