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Income Taxes - Reconciliation Between Expected Income Tax Provision at Federal Statutory Rate and Reported Income Tax Benefit (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Reconciliation Of Effective Income Tax Rate [Line Items]      
U.S. federal statutory income tax rate 21.00% 21.00% 21.00%
Foreign tax at less than federal statutory rate (0.20%) 0.90% (0.30%)
Prior year tax rate adjustment   (1.90%)  
State taxes, net of federal benefit 0.70% 2.70% 2.40%
Research and development tax credit (1.60%) 1.80% 2.00%
Permanent items 1.80% 1.30% (0.80%)
Changes in valuation allowance (17.90%) (25.30%) (24.30%)
Other 0.10% (0.50%) (0.10%)
Effective income tax rate 3.90% 0.00% (0.10%)