X0306 4 2019-10-10 0 0001404644 Neoleukin Therapeutics, Inc. NLTX 0001706301 Noonberg Sarah B. C/O NEOLEUKIN THERAPEUTICS, INC. 401 TERRY AVENUE NORTH SEATTLE WA 98109 1 0 0 0 Stock Option (right to buy) 2.82 2019-10-10 4 A 0 22000 0.00 A 2029-10-09 Common Stock 22000 22000 D The options will vest as to 1/3 of the total number of shares underlying the options on each of October 10, 2020, October 10, 2021 and October 10, 2022, subject to the Reporting Person's provision of service to the Issuer on each vesting date. /s/ Kamran Alam, Attorney-in-fact for Sarah B. Noonberg 2019-10-15