X0306 4/A 2019-05-14 2019-05-16 0 0001505512 Regulus Therapeutics Inc. RGLS 0001706176 Chevallard Daniel R. C/O REGULUS THERAPEUTICS INC. 10628 SCIENCE CENTER DR., #100 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Stock Option (Right to Buy) 0.95 2019-05-14 4 A 0 8000 0.00 A 2019-05-14 2029-02-04 Common Stock 8000 8000 D On February 5, 2019, the reporting person was granted an option to purchase the number of shares of common stock set forth in Box 5. The option vests only upon the achievement of a performance-based milestone. The performance criteria were met, resulting in vesting of the option. Upon achievement of the milestone, 50% of the options subject to the milestone immediately vest, with the remaining options vesting in 24 equal monthly installments following the vesting commencement date. The original Form 4, filed on May 16, 2019, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported the number of shares reported in Boxes 7 and 9. As a result of this administrative error, the number of shares beneficially owned by the reporting person following the reported transaction was incorrectly reported. Christopher Aker, Attorney in Fact 2019-05-16