Consolidated Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues
Product revenue, net	$ 397,614,000	$ 266,719,000	$ 212,672,000
Collaboration revenue	1,374,000	0	2,368,000
Total revenues	398,988,000	266,719,000	215,040,000
Expenses
Cost of product revenue	(147,118,000)	(95,816,000)	(74,018,000)
Cost of collaboration revenue	(742,000)	0	0
Research and development	(234,504,000)	(265,868,000)	(286,408,000)
Selling, general and administrative	(298,741,000)	(281,608,000)	(258,971,000)
Gain on sale of intellectual property	0	10,000,000	0
Loss from operations	(282,117,000)	(366,573,000)	(404,357,000)
Interest income	37,105,000	39,797,000	14,582,000
Interest expenses	(2,254,000)	0	0
Foreign currency losses	(15,137,000)	(14,850,000)	(56,403,000)
Other income, net	5,300,000	7,006,000	3,113,000
Loss before income tax and share of loss from equity method investment	(257,103,000)	(334,620,000)	(443,065,000)
Income tax expense	0	0	0
Share of loss from equity method investment	0	0	(221,000)
Net loss	$ (257,103,000)	$ (334,620,000)	$ (443,286,000)
Loss per share — basic (in dollars per share)	$ (0.26)	$ (0.35)	$ (0.46)
Loss per share — diluted (in dollars per share)	$ (0.26)	$ (0.35)	$ (0.46)
Weighted-average shares used in calculating net loss per ordinary share — basic (in shares)	989,477,730	966,394,130	958,067,140
Weighted-average shares used in calculating net loss per ordinary share —diluted (in shares)	989,477,730	966,394,130	958,067,140