Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Total	Ordinary shares	Additional paid in capital	Accumulated deficit	Accumulated other comprehensive income (loss)	Treasury Stock
Beginning balance (in shares) at Dec. 31, 2020		878,110,260
Beginning balance at Dec. 31, 2020	$ 1,169,345	$ 5	$ 1,897,467	$ (713,603)	$ (14,524)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		2,054,500
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares options (in shares)		12,353,400
Exercise of share options	7,417	$ 0	7,417
Issuance of ordinary shares upon follow-on public offering, net of issuance cost (in shares)		57,164,000
Issuance of ordinary shares upon follow-on public offering, net of issuance cost	818,036	$ 1	818,035
Issuance of ordinary shares in connection with collaboration and license arrangement (Note 16) (in shares)		5,681,820
Issuance of ordinary shares in connection with collaboration and license arrangement (Note 16)	62,250	$ 0	62,250
Issuance cost adjustment for secondary listing	65		65
Receipt of shares netted to satisfy tax withholding obligations related to share-based compensation (in shares)						(382,930)
Receipt of shares netted to satisfy tax withholding obligations related to share-based compensation	(4,279)					$ (4,279)
Share-based compensation	40,714		40,714
Net loss	(704,471)			(704,471)
Foreign currency translation	(9,121)				(9,121)
Ending balance (in shares) at Dec. 31, 2021		955,363,980
Ending balance at Dec. 31, 2021	1,379,956	$ 6	2,825,948	(1,418,074)	(23,645)	$ (4,279)
Ending balance (in shares) at Dec. 31, 2021						(382,930)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		1,940,680
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares options (in shares)		5,151,190
Exercise of share options	5,870	$ 0	5,870
Receipt of shares netted to satisfy tax withholding obligations related to share-based compensation (in shares)						(1,853,350)
Receipt of shares netted to satisfy tax withholding obligations related to share-based compensation	(7,577)					$ (7,577)
Share-based compensation	61,302		61,302
Net loss	(443,286)			(443,286)
Foreign currency translation	$ 49,330				49,330
Ending balance (in shares) at Dec. 31, 2022	960,219,570	962,455,850
Ending balance at Dec. 31, 2022	$ 1,045,595	$ 6	2,893,120	(1,861,360)	25,685	$ (11,856)
Ending balance (in shares) at Dec. 31, 2022	(2,236,280)					(2,236,280)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		8,178,500
Issuance of ordinary shares upon vesting of restricted shares	$ 0	$ 0	0
Exercise of shares options (in shares)	6,516,920	6,516,920
Exercise of share options	$ 2,548	$ 0	2,548
Receipt of shares netted to satisfy tax withholding obligations related to share-based compensation (in shares)						(2,675,920)
Receipt of shares netted to satisfy tax withholding obligations related to share-based compensation	(8,980)					$ (8,980)
Share-based compensation	79,634		79,634
Net loss	(334,620)			(334,620)
Foreign currency translation	$ 11,941				11,941
Ending balance (in shares) at Dec. 31, 2023	972,239,070	977,151,270
Ending balance at Dec. 31, 2023	$ 796,118	$ 6	$ 2,975,302	$ (2,195,980)	$ 37,626	$ (20,836)
Ending balance (in shares) at Dec. 31, 2023	(4,912,200)					(4,912,200)