Unaudited Condensed Consolidated Statements of Operations - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Revenues:
Product revenue, net	$ 69,228,000	$ 56,963,000	$ 200,889,000	$ 150,633,000
Collaboration revenue	0	577,000	0	1,806,000
Total revenues	69,228,000	57,540,000	200,889,000	152,439,000
Expenses:
Cost of sales	(25,479,000)	(20,044,000)	(70,579,000)	(53,094,000)
Research and development	(58,767,000)	(99,524,000)	(183,920,000)	(219,462,000)
Selling, general, and administrative	(68,552,000)	(66,555,000)	(198,982,000)	(186,947,000)
Gain on sale of intellectual property	0	0	10,000,000	0
Loss from operations	(83,570,000)	(128,583,000)	(242,592,000)	(307,064,000)
Interest income	9,172,000	3,872,000	29,493,000	5,235,000
Foreign currency gain (loss)	4,852,000	(40,442,000)	(26,315,000)	(73,052,000)
Other income (expense), net	394,000	3,963,000	223,000	(6,415,000)
Loss before income tax and share of loss from equity method investment	(69,152,000)	(161,190,000)	(239,191,000)	(381,296,000)
Income tax expense	0	0	0	0
Share of loss from equity method investment	0	0	0	(221,000)
Net loss	(69,152,000)	(161,190,000)	(239,191,000)	(381,517,000)
Net loss attributable to ordinary shareholders - basic	(69,152,000)	(161,190,000)	(239,191,000)	(381,517,000)
Net loss attributable to ordinary shareholders - diluted	$ (69,152,000)	$ (161,190,000)	$ (239,191,000)	$ (381,517,000)
Loss per share/ADS - basic (in dollars per share)	$ (0.07)	$ (0.17)	$ (0.25)	$ (0.40)
Loss per share/ADS - diluted (in dollars per share)	$ (0.07)	$ (0.17)	$ (0.25)	$ (0.40)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	968,767,730	959,085,960	965,060,570	957,439,910
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	968,767,730	959,085,960	965,060,570	957,439,910
American Depositary Shares
Expenses:
Loss per share/ADS - basic (in dollars per share)	$ (0.71)	$ (1.68)	$ (2.48)	$ (3.98)
Loss per share/ADS - diluted (in dollars per share)	$ (0.71)	$ (1.68)	$ (2.48)	$ (3.98)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	96,876,773	95,908,596	96,506,057	95,743,991
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	96,876,773	95,908,596	96,506,057	95,743,991