Unaudited Condensed Consolidated Statements of Operations - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenues:
Product revenue, net	$ 68,864,000	$ 47,575,000	$ 131,661,000	$ 93,670,000
Collaboration revenue	0	601,000	0	1,230,000
Total revenues	68,864,000	48,176,000	131,661,000	94,900,000
Expenses:
Cost of sales	(23,763,000)	(17,407,000)	(45,100,000)	(33,051,000)
Research and development	(76,682,000)	(66,084,000)	(125,153,000)	(119,938,000)
Selling, general, and administrative	(67,920,000)	(63,401,000)	(130,430,000)	(120,392,000)
Gain on sale of intellectual property	10,000,000	0	10,000,000	0
Loss from operations	(89,501,000)	(98,716,000)	(159,022,000)	(178,481,000)
Interest income	10,090,000	1,175,000	20,321,000	1,363,000
Foreign currency loss	(40,079,000)	(34,895,000)	(31,167,000)	(32,610,000)
Other expense, net	(1,405,000)	(5,497,000)	(171,000)	(10,378,000)
Loss before income tax and share of loss from equity method investment	(120,895,000)	(137,933,000)	(170,039,000)	(220,106,000)
Income tax expense	0	0	0	0
Share of loss from equity method investment	0	0	0	(221,000)
Net loss	(120,895,000)	(137,933,000)	(170,039,000)	(220,327,000)
Net loss attributable to ordinary shareholders - basic	(120,895,000)	(137,933,000)	(170,039,000)	(220,327,000)
Net loss attributable to ordinary shareholders - diluted	$ (120,895,000)	$ (137,933,000)	$ (170,039,000)	$ (220,327,000)
Loss per share/ADS - basic (in dollars per share)	$ (0.13)	$ (0.14)	$ (0.18)	$ (0.23)
Loss per share/ADS - diluted (in dollars per share)	$ (0.13)	$ (0.14)	$ (0.18)	$ (0.23)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	964,817,310	957,684,820	963,140,360	956,603,250
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	964,817,310	957,684,820	963,140,360	956,603,250
American Depositary Shares
Expenses:
Loss per share/ADS - basic (in dollars per share)	$ (1.25)	$ (1.44)	$ (1.77)	$ (2.30)
Loss per share/ADS - diluted (in dollars per share)	$ (1.25)	$ (1.44)	$ (1.77)	$ (2.30)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	96,481,731	95,768,482	96,314,036	95,660,325
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	96,481,731	95,768,482	96,314,036	95,660,325