XML 124 R80.htm IDEA: XBRL DOCUMENT v3.22.4
License and Collaboration Agreements (Details)
$ / shares in Units, $ in Millions
1 Months Ended 2 Months Ended 4 Months Ended 6 Months Ended 7 Months Ended 8 Months Ended 12 Months Ended 24 Months Ended 43 Months Ended 50 Months Ended 56 Months Ended 57 Months Ended 61 Months Ended 69 Months Ended 76 Months Ended
Jul. 31, 2021
USD ($)
$ / shares
shares
Jun. 30, 2021
USD ($)
program
molecule
Jan. 31, 2021
USD ($)
shares
Dec. 31, 2021
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
$ / shares
Dec. 31, 2018
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2021
USD ($)
$ / shares
Dec. 31, 2021
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
payment
$ / shares
Dec. 31, 2021
USD ($)
payment
$ / shares
Dec. 31, 2020
USD ($)
payment
Dec. 31, 2018
USD ($)
Dec. 31, 2022
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
payment
$ / shares
Dec. 31, 2022
USD ($)
payment
$ / shares
Dec. 31, 2022
USD ($)
payment
$ / shares
Dec. 31, 2022
USD ($)
payment
$ / shares
Dec. 31, 2022
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
$ / shares
Dec. 31, 2022
USD ($)
$ / shares
Mar. 30, 2022
$ / shares
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Maximum additional milestone payments         $ 5,300.4         $ 5,300.4       $ 5,300.4 $ 5,300.4 $ 5,300.4 $ 5,300.4 $ 5,300.4 $ 5,300.4 $ 5,300.4 $ 5,300.4  
Common stock, par value (in dollars per share) | $ / shares       $ 0.000006 $ 0.000006     $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006     $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006 $ 0.000006
MacroGenics                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Issuance of common stock (in shares) | shares 958,467                                          
Common stock, par value (in dollars per share) | $ / shares $ 0.01                                          
Issue price per share (in dollars per share) | $ / shares $ 31.30                                          
MacroGenics                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Equity investment $ 30.0                                          
GSK                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                                         $ 15.0  
Milestone payment                   $ 4.0 $ 1.0                   16.5  
Development milestone payment                   3.5                        
Sales-based milestone payment                   8.0                        
Maximum additional milestone payments         $ 28.0         28.0       $ 28.0 $ 28.0 $ 28.0 $ 28.0 $ 28.0 $ 28.0 $ 28.0 28.0  
Paratek                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                                       7.5    
Milestone payment                                       14.0    
Development milestone payment                   6.0   $ 3.0 $ 5.0                  
Maximum additional milestone payments         40.5         40.5       40.5 40.5 40.5 40.5 40.5 40.5 40.5 40.5  
Amgen                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                                     5.0      
Milestone payment                                     2.0      
Maximum additional milestone payments         37.0         37.0       37.0 37.0 37.0 37.0 37.0 37.0 37.0 37.0  
Entasis                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                                   5.0        
Development milestone payment                                   7.0        
Maximum additional milestone payments         91.6         91.6       91.6 91.6 91.6 91.6 $ 91.6 91.6 91.6 91.6  
Number of milestone payments | payment                                   2        
Crescendo                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                       2.5         4.5          
Milestone payment                     4.0 2.0         6.0          
Maximum additional milestone payments         298.1         298.1       298.1 298.1 298.1 $ 298.1 $ 298.1 298.1 298.1 298.1  
Number of milestone payments | payment                                 3          
Number of up front payments | payment                                 2          
Novocure                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment           $ 15.0                                
Milestone payment                       $ 10.0                    
Maximum additional milestone payments         68.0         68.0       68.0 68.0 68.0 $ 68.0 68.0 68.0 68.0 68.0  
Number of milestone payments | payment                       2                    
MacroGenics Inc, November 2018 Agreement                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                               25.0            
Milestone payment                   5.0   $ 4.0       9.0            
Maximum additional milestone payments         84.0         84.0       84.0 84.0 $ 84.0 84.0 84.0 84.0 84.0 84.0  
Number of milestone payments | payment                               3            
MacroGenics Inc. June 2021 Agreement                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment               $ 25.0                            
Maximum additional milestone payments         1,386.0         1,386.0       1,386.0 1,386.0 $ 1,386.0 1,386.0 1,386.0 1,386.0 1,386.0 1,386.0  
Number of programs | program   4                                        
Profit share percentage upon reaching clinical milestone   50.00%                                        
Number of additional molecules | molecule   2                                        
Profit share percentage as an alternative to the royalty arrangement   50.00%                                        
Profit share payment to be made as an alternative to the royalty arrangement   $ 85.0                                        
Deciphera                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                             20.0              
Milestone payment                     5.0 2.0     12.0              
Maximum additional milestone payments         173.0         173.0       173.0 $ 173.0 173.0 173.0 173.0 173.0 173.0 173.0  
Number of milestone payments | payment                             3              
Regeneron                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                       $ 30.0                    
Maximum additional milestone payments         160.0         160.0       160.0 $ 160.0 160.0 160.0 160.0 160.0 160.0 160.0  
Turning Point Therapeutics Inc, July 2020 Agreement                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment             $ 25.0                              
Milestone payment                     $ 5.0                      
Maximum additional milestone payments         146.0         146.0       146.0 146.0 146.0 146.0 146.0 146.0 146.0 146.0  
Number of milestone payments | payment                     3                      
Turning Point Therapeutics Inc, January 2021 Agreement                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                           25.0                
Maximum additional milestone payments         336.0         336.0       336.0 336.0 336.0 336.0 336.0 336.0 336.0 336.0  
Cullinan Pearl Corp                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                     $ 20.0                      
Maximum additional milestone payments         211.0         211.0       211.0 211.0 211.0 211.0 211.0 211.0 211.0 211.0  
Takeda                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                     6.0                      
argenx                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment     $ 62.3                                      
Milestone payment                   25.0                        
Issuance of ordinary shares in connection with collaboration and license arrangement (in shares) | shares     5,681,820                                      
Development cost sharing payment                     75.0                      
Mirati                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                 $ 65.0                          
Development milestone payment                   10.0                        
Maximum additional milestone payments         263.0         $ 263.0       263.0 263.0 263.0 263.0 263.0 263.0 263.0 263.0  
Number of milestone payments | payment                   2                        
Blueprint                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment                     $ 25.0                      
Maximum additional milestone payments         590.0         $ 590.0       590.0 590.0 590.0 590.0 590.0 590.0 590.0 590.0  
Karuna                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment       $ 35.0                                    
Development milestone payment                   10.0                        
Maximum additional milestone payments         142.0         $ 142.0       142.0 142.0 142.0 142.0 142.0 142.0 142.0 142.0  
Number of milestone payments | payment                   2                        
Seagen                                            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                                            
Upfront payment         30.0                                  
Maximum additional milestone payments         $ 263.0         $ 263.0       $ 263.0 $ 263.0 $ 263.0 $ 263.0 $ 263.0 $ 263.0 $ 263.0 $ 263.0