Consolidated Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues
Product revenue, net	$ 212,672,000	$ 144,105,000	$ 48,958,000
Collaboration revenue	2,368,000	207,000	0
Total revenues	215,040,000	144,312,000	48,958,000
Expenses
Cost of sales	(74,018,000)	(52,239,000)	(16,736,000)
Research and development	(286,408,000)	(573,306,000)	(222,711,000)
Selling, general and administrative	(258,971,000)	(218,831,000)	(111,312,000)
Loss from operations	(404,357,000)	(700,064,000)	(301,801,000)
Interest income	14,582,000	2,190,000	5,120,000
Interest expenses	0	0	(181,000)
Foreign currency (loss) gain	(56,403,000)	4,661,000	21,659,000
Other income (expenses), net	3,113,000	(10,201,000)	7,417,000
Loss before income tax and share of loss from equity method investment	(443,065,000)	(703,414,000)	(267,786,000)
Income tax expense	0	0	0
Share of loss from equity method investment	(221,000)	(1,057,000)	(1,119,000)
Net loss	$ (443,286,000)	$ (704,471,000)	$ (268,905,000)
Loss per share — basic (in dollars per share)	$ (0.46)	$ (0.76)	$ (0.35)
Loss per share — diluted (in dollars per share)	$ (0.46)	$ (0.76)	$ (0.35)
Weighted-average shares used in calculating net loss per ordinary share — basic (in shares)	958,067,140	929,921,120	776,677,430
Weighted-average shares used in calculating net loss per ordinary share —diluted (in shares)	958,067,140	929,921,120	776,677,430
American Depositary Shares
Expenses
Loss per share — basic (in dollars per share)	$ (4.63)	$ (7.58)	$ (3.46)
Loss per share — diluted (in dollars per share)	$ (4.63)	$ (7.58)	$ (3.46)
Weighted-average shares used in calculating net loss per ordinary share — basic (in shares)	95,806,714	92,992,112	77,667,743
Weighted-average shares used in calculating net loss per ordinary share —diluted (in shares)	95,806,714	92,992,112	77,667,743