Unaudited condensed consolidated statements of operations - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues:
Product revenue, net	$ 56,963,000	$ 43,103,000	$ 150,633,000	$ 100,141,000
Collaboration revenue	577,000	0	1,806,000	0
Total revenues	57,540,000	43,103,000	152,439,000	100,141,000
Expenses:
Cost of sales	(20,044,000)	(12,162,000)	(53,094,000)	(30,535,000)
Research and development	(99,524,000)	(55,144,000)	(219,462,000)	(401,220,000)
Selling, general, and administrative	(66,555,000)	(59,002,000)	(186,947,000)	(149,254,000)
Loss from operations	(128,583,000)	(83,205,000)	(307,064,000)	(480,868,000)
Interest income	3,872,000	713,000	5,235,000	1,171,000
Other income (expenses), net	(36,479,000)	(13,580,000)	(79,467,000)	(12,401,000)
Loss before income tax and share of loss from equity method investment	(161,190,000)	(96,072,000)	(381,296,000)	(492,098,000)
Income tax expense	0	0	0	0
Share of loss from equity method investment	0	(340,000)	(221,000)	(548,000)
Net loss	(161,190,000)	(96,412,000)	(381,517,000)	(492,646,000)
Net loss attributable to ordinary shareholders - basic	(161,190,000)	(96,412,000)	(381,517,000)	(492,646,000)
Net loss attributable to ordinary shareholders - diluted	$ (161,190,000)	$ (96,412,000)	$ (381,517,000)	$ (492,646,000)
Loss per share/ADS - basic (in dollars per share)	$ (0.17)	$ (0.10)	$ (0.40)	$ (0.53)
Loss per share/ADS - diluted (in dollars per share)	$ (0.17)	$ (0.10)	$ (0.40)	$ (0.53)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	959,085,960	950,354,320	957,439,910	921,748,380
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	959,085,960	950,354,320	957,439,910	921,748,380
American Depositary Shares
Expenses:
Loss per share/ADS - basic (in dollars per share)	$ (1.68)	$ (1.01)	$ (3.98)	$ (5.34)
Loss per share/ADS - diluted (in dollars per share)	$ (1.68)	$ (1.01)	$ (3.98)	$ (5.34)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	95,908,596	95,035,432	95,743,991	92,174,838
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	95,908,596	95,035,432	95,743,991	92,174,838