Unaudited condensed consolidated statements of shareholders' equity - USD ($) $ in Thousands	Total	Ordinary Shares	Additional paid in capital	Accumulated deficit	Accumulated other comprehensive (loss) income	Treasury Stock
Beginning balance (in shares) at Dec. 31, 2020		878,110,260
Beginning balance at Dec. 31, 2020	$ 1,169,345	$ 5	$ 1,897,467	$ (713,603)	$ (14,524)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		816,000
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares options (in shares)		583,640
Exercise of shares options	702	$ 0	702
Issuance of ordinary shares in connection with collaboration and license arrangement/ follow-on public offering, net of issuance cost (in shares)		5,681,820
Issuance of ordinary shares in connection with collaboration and license arrangement/ follow-on public offering, net of issuance cost	62,250	$ 0	62,250
Issuance cost adjustment for secondary listing	65		65
Share-based compensation	7,318		7,318
Net loss	(232,910)			(232,910)
Foreign currency translation	2,900				2,900
Ending balance (in shares) at Mar. 31, 2021		885,191,720
Ending balance at Mar. 31, 2021	1,009,670	$ 5	1,967,802	(946,513)	(11,624)	$ 0
Ending balance (in shares) at Mar. 31, 2021						0
Beginning balance (in shares) at Dec. 31, 2020		878,110,260
Beginning balance at Dec. 31, 2020	1,169,345	$ 5	1,897,467	(713,603)	(14,524)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(396,234)
Foreign currency translation	(2,341)
Ending balance (in shares) at Jun. 30, 2021		947,581,890
Ending balance at Jun. 30, 2021	1,671,698	$ 6	2,799,318	(1,109,837)	(16,865)	$ (924)
Ending balance (in shares) at Jun. 30, 2021						(60,860)
Beginning balance (in shares) at Mar. 31, 2021		885,191,720
Beginning balance at Mar. 31, 2021	1,009,670	$ 5	1,967,802	(946,513)	(11,624)	$ 0
Beginning balance (in shares) at Mar. 31, 2021						0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		321,000
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares options (in shares)		4,905,170
Exercise of shares options	3,289	$ 0	3,289
Issuance of ordinary shares in connection with collaboration and license arrangement/ follow-on public offering, net of issuance cost (in shares)		57,164,000
Issuance of ordinary shares in connection with collaboration and license arrangement/ follow-on public offering, net of issuance cost	817,996	$ 1	817,995
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation (in shares)						(60,860)
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation	(924)					$ (924)
Share-based compensation	10,232		10,232
Net loss	(163,324)			(163,324)
Foreign currency translation	(5,241)				(5,241)
Ending balance (in shares) at Jun. 30, 2021		947,581,890
Ending balance at Jun. 30, 2021	$ 1,671,698	$ 6	2,799,318	(1,109,837)	(16,865)	$ (924)
Ending balance (in shares) at Jun. 30, 2021						(60,860)
Beginning balance (in shares) at Dec. 31, 2021	954,981,050	955,363,980
Beginning balance at Dec. 31, 2021	$ 1,379,956	$ 6	2,825,948	(1,418,074)	(23,645)	$ (4,279)
Beginning balance (in shares) at Dec. 31, 2021	(382,930)					(382,930)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		514,800
Issuance of ordinary shares upon vesting of restricted shares	$ 0	$ 0	0
Exercise of shares options (in shares)		1,156,660
Exercise of shares options	297	$ 0	297
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation (in shares)						(15,150)
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation	(68)					$ (68)
Share-based compensation	12,410		12,410
Net loss	(82,394)			(82,394)
Foreign currency translation	(2,193)				(2,193)
Ending balance (in shares) at Mar. 31, 2022		957,035,440
Ending balance at Mar. 31, 2022	$ 1,308,008	$ 6	2,838,655	(1,500,468)	(25,838)	$ (4,347)
Ending balance (in shares) at Mar. 31, 2022						(398,080)
Beginning balance (in shares) at Dec. 31, 2021	954,981,050	955,363,980
Beginning balance at Dec. 31, 2021	$ 1,379,956	$ 6	2,825,948	(1,418,074)	(23,645)	$ (4,279)
Beginning balance (in shares) at Dec. 31, 2021	(382,930)					(382,930)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	$ (220,327)
Foreign currency translation	$ 28,132
Ending balance (in shares) at Jun. 30, 2022	958,494,830	960,520,140
Ending balance at Jun. 30, 2022	$ 1,212,165	$ 6	2,857,202	(1,638,401)	4,487	$ (11,129)
Ending balance (in shares) at Jun. 30, 2022	(2,025,310)					(2,025,310)
Beginning balance (in shares) at Mar. 31, 2022		957,035,440
Beginning balance at Mar. 31, 2022	$ 1,308,008	$ 6	2,838,655	(1,500,468)	(25,838)	$ (4,347)
Beginning balance (in shares) at Mar. 31, 2022						(398,080)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares upon vesting of restricted shares (in shares)		683,700
Issuance of ordinary shares upon vesting of restricted shares	0	$ 0	0
Exercise of shares options (in shares)		2,801,000
Exercise of shares options	4,322	$ 0	4,322
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation (in shares)						(1,627,230)
Receipt of employees’ shares to satisfy tax withholding obligations related to share-based compensation	(6,782)					$ (6,782)
Share-based compensation	14,225		14,225
Net loss	(137,933)			(137,933)
Foreign currency translation	$ 30,325				30,325
Ending balance (in shares) at Jun. 30, 2022	958,494,830	960,520,140
Ending balance at Jun. 30, 2022	$ 1,212,165	$ 6	$ 2,857,202	$ (1,638,401)	$ 4,487	$ (11,129)
Ending balance (in shares) at Jun. 30, 2022	(2,025,310)					(2,025,310)